2. Gene
  3. Prnp - prion protein Gene

Prnp - prion protein Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: PrP; Prn

基因 ID: 24686 | 基因类型: protein coding

关于 Prnp

功能概要

Enables several functions, including ATP-dependent protein binding activity; chaperone binding activity; and lamin binding activity. Involved in several processes, including negative regulation of long-term synaptic potentiation; positive regulation of protein localization to plasma membrane; and response to copper ion. Located in cytoplasm; plasma membrane; and postsynaptic density. Used to study hyperglycemia and scrapie. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease; Gerstmann-Straussler-Scheinker syndrome; Huntington's disease-like 1; fatal familial insomnia; and kuru. Orthologous to human PRNP (Prion Protein). [provided by Alliance of Genome Resources, Apr 2022]

Prnp 基因产物(2)

mRNA Protein Name
NM_001395658.1 NP_001382587.1 major prion protein precursor
NM_012631.3 NP_036763.1 major prion protein precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP-dependent protein binding IPI
IPI: 通过物理相互作用推断
16774738 RGD
enables lamin binding IPI
IPI: 通过物理相互作用推断
21277044 RGD
enables protein-folding chaperone binding IPI
IPI: 通过物理相互作用推断
16774738 RGD
enables transmembrane transporter binding IPI
IPI: 通过物理相互作用推断
16750514 RGD
enables type 5 metabotropic glutamate receptor binding IPI
IPI: 通过物理相互作用推断
24012003 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in learning or memory IMP
IMP: 通过突变表型推断
17156386 RGD
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
16766127 RGD
involved in negative regulation of catalytic activity IDA
IDA: 通过直接分析推断
23386614 RGD
involved in negative regulation of long-term synaptic potentiation IDA
IDA: 通过直接分析推断
21593310 RGD
involved in positive regulation of protein localization to plasma membrane IMP
IMP: 通过突变表型推断
23386614 RGD
involved in response to cadmium ion IDA
IDA: 通过直接分析推断
16148034 RGD
involved in response to copper ion IDA
IDA: 通过直接分析推断
16148034 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in postsynaptic density IDA
IDA: 通过直接分析推断
22820466 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

major prion protein

prion protein, PrP

prion protein, structural

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11188 PRNP Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18367 Prnp Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24846 Prnp Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Prnp NCBI NCBI:5621
Mus musculus Prnp NCBI NCBI:19122
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