2. Gene
  3. Adra2a - adrenoceptor alpha 2A Gene

Adra2a - adrenoceptor alpha 2A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: RG20; CA2-47; RATRG20

基因 ID: 25083 | 基因类型: protein coding

关于 Adra2a

功能概要

Enables alpha2-adrenergic receptor activity. Involved in several processes, including glucose homeostasis; negative regulation of secretion by cell; and negative regulation of uterine smooth muscle contraction. Located in several cellular components, including axon terminus; neuronal cell body; and plasma membrane. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic active zone membrane. Used to study anxiety disorder and mental depression. Biomarker of hypertension and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and type 2 diabetes mellitus. Orthologous to human ADRA2A (adrenoceptor alpha 2A). [provided by Alliance of Genome Resources, Apr 2022]

Adra2a 基因产物(1)

mRNA Protein Name
NM_012739.3 NP_036871.3 alpha-2A adrenergic receptor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables alpha2-adrenergic receptor activity IDA
IDA: 通过直接分析推断
1645350 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA replication IMP
IMP: 通过突变表型推断
15351511 RGD
involved in G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
19965390 RGD
involved in female pregnancy IMP
IMP: 通过突变表型推断
19450576 RGD
involved in glucose homeostasis IMP
IMP: 通过突变表型推断
19965390 RGD
involved in negative regulation of calcium ion-dependent exocytosis IMP
IMP: 通过突变表型推断
19965390 RGD
involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: 通过突变表型推断
19965390 RGD
involved in negative regulation of uterine smooth muscle contraction IMP
IMP: 通过突变表型推断
17664026 RGD
involved in response to alcohol IEP
IEP: 通过表达模式推断
26121187 RGD
involved in response to morphine IEP
IEP: 通过表达模式推断
9105684 RGD
involved in thermoception IDA
IDA: 通过直接分析推断
20110357 RGD
involved in vasodilation IDA
IDA: 通过直接分析推断
20837990 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in GABA-ergic synapse IDA
IDA: 通过直接分析推断
9596526 RGD
located in axon terminus IDA
IDA: 通过直接分析推断
12379250 RGD
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
9596526 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
9596526 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
12379250 RGD
is active in postsynaptic density membrane IDA
IDA: 通过直接分析推断
9596526 RGD
is active in postsynaptic membrane EXP
EXP: 通过实验结果推断
9596526 RGD
is active in postsynaptic membrane IDA
IDA: 通过直接分析推断
9596526 RGD
is active in presynaptic active zone membrane IDA
IDA: 通过直接分析推断
9596526 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

alpha-2A adrenergic receptor

adrenergic receptor, alpha 2a

adrenergic, alpha-2A-, receptor

alpha-2A adrenoceptor

alpha-2A adrenoreceptor

alpha-2AAR

alpha-2D adrenergic receptor

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N8728 Aposcopolamine 98.44% 否
HY-145700 UCSF648 / 否
HY-163694 ADRA2A antagonist 1 Antagonist / 否
HY-RS00411 ADRA2A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-134125 Yohimbic acid ethyl ester Antagonist / 否
HY-RS17718 Adra2a Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24183 Adra2a Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Adra2a NCBI NCBI:150
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