2. Gene
  3. Slc11a2 - solute carrier family 11 member 2 Gene

Slc11a2 - solute carrier family 11 member 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Dmt1; Nramp2

基因 ID: 25715 | 基因类型: protein coding

关于 Slc11a2

功能概要

Enables lead ion transmembrane transporter activity; transition metal ion binding activity; and transition metal ion transmembrane transporter activity. Involved in several processes, including cellular response to tumor necrosis factor; response to lead ion; and transition metal ion transport. Located in apical part of cell; late endosome membrane; and lysosomal membrane. Is integral component of membrane. Used to study Parkinsonism; hypochromic anemia; and pneumonia. Biomarker of brain ischemia; duodenal ulcer; and iron deficiency anemia. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; anemia; and hypochromic anemia. Orthologous to human SLC11A2 (solute carrier family 11 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc11a2 基因产物(2)

mRNA Protein Name
NM_001399169.1 NP_001386098.1 natural resistance-associated macrophage protein 2 isoform 2
NM_013173.2 NP_037305.2 natural resistance-associated macrophage protein 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cadmium ion binding IDA
IDA: 通过直接分析推断
9242408 RGD
enables cadmium ion transmembrane transporter activity IDA
IDA: 通过直接分析推断
9242408 RGD
enables cobalt ion binding IDA
IDA: 通过直接分析推断
9242408 RGD
enables cobalt ion transmembrane transporter activity IDA
IDA: 通过直接分析推断
9242408 RGD
enables copper ion binding IDA
IDA: 通过直接分析推断
9242408 RGD
enables copper ion transmembrane transporter activity IDA
IDA: 通过直接分析推断
9242408 RGD
enables ferrous iron transmembrane transporter activity IMP
IMP: 通过突变表型推断
16091957 RGD
enables iron ion binding IDA
IDA: 通过直接分析推断
9242408 RGD
enables iron ion transmembrane transporter activity IDA
IDA: 通过直接分析推断
9242408 RGD
enables lead ion transmembrane transporter activity IDA
IDA: 通过直接分析推断
9242408 RGD
enables manganese ion binding IDA
IDA: 通过直接分析推断
9242408 RGD
enables manganese ion transmembrane transporter activity IDA
IDA: 通过直接分析推断
9242408 RGD
enables nickel cation binding IDA
IDA: 通过直接分析推断
9242408 RGD
enables nickel cation transmembrane transporter activity IDA
IDA: 通过直接分析推断
9242408 RGD
enables zinc ion binding IDA
IDA: 通过直接分析推断
9242408 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
21325818 RGD
involved in cellular response to iron ion IEP
IEP: 通过表达模式推断
17663481 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: 通过表达模式推断
16221503 RGD
involved in copper ion import across plasma membrane IMP
IMP: 通过突变表型推断
22442359 RGD
involved in iron ion transport IMP
IMP: 通过突变表型推断
16091957 RGD
involved in response to cadmium ion IEP
IEP: 通过表达模式推断
19083094 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
21325818 RGD
involved in response to iron ion IEP
IEP: 通过表达模式推断
12876064 RGD
involved in response to lead ion IEP
IEP: 通过表达模式推断
19083094 RGD
involved in response to manganese ion IEP
IEP: 通过表达模式推断
17060373 RGD
involved in response to manganese ion IMP
IMP: 通过突变表型推断
18849539 RGD
involved in transition metal ion transport IDA
IDA: 通过直接分析推断
9242408 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical part of cell IDA
IDA: 通过直接分析推断
18420243 RGD
located in late endosome membrane IDA
IDA: 通过直接分析推断
16449358 RGD
located in lysosomal membrane IDA
IDA: 通过直接分析推断
16449358 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

natural resistance-associated macrophage protein 2

DMT-1

NRAMP 2

Solute carrier family 11 member 2 (natural resistance-associated macrophage protein 2)

divalent cation transporter 1

divalent metal transporter 1

solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2

solute

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12995 SLC11A2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20644 Slc11a2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27154 Slc11a2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Slc11a2 NCBI NCBI:4891
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