NARF - nuclear prelamin A recognition factor Gene

中文名称：核 prelamin A 识别因子

种属: Homo sapiens

同用名: IOP2

关于 NARF

功能概要

已发现几种蛋白质在其羧基末端被异戊二烯化和甲基化。最初认为异戊二烯化仅对膜附着很重要。然而，异戊二烯化的另一个作用似乎是它在蛋白质-蛋白质相互作用中的重要性。已知在哺乳动物细胞中被异戊二烯化的唯一核蛋白是前核纤层蛋白 A 型和 B 型核纤层蛋白。 Prelamin A 在羧基末端 CaaX 基序的半胱氨酸残基上被法尼基化和羧甲基化。这种翻译后修饰的半胱氨酸残基在内切蛋白水解加工成成熟的核纤层蛋白 A 时从 prelamin A 中去除。该基因编码的蛋白质与异戊二烯化的 prelamin A 羧基末端尾域结合。它可能是 prelamin A 内切蛋白酶复合物的成分。编码的蛋白质位于细胞核中，在那里它与核层部分共定位。它与仅含铁的细菌氢化酶具有有限的序列相似性。已经为该基因鉴定了编码不同亚型的可变剪接转录物变体，包括一个具有通过 RNA 编辑产生的新外显子的变体。[RefSeq 提供，2008 年 7 月]

Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only Bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. [provided by RefSeq, Jul 2008]