2. Gene
  3. DIMT1 - DIM1 rRNA methyltransferase and ribosome maturation factor Gene

DIMT1 - DIM1 rRNA methyltransferase and ribosome maturation factor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：DIM1 rRNA 甲基转移酶和核糖体成熟因子

种属: Homo sapiens

同用名: DIM1; DIMT1L; HUSSY5; HSA9761

基因 ID: 27292 | 基因类型: protein coding

关于 DIMT1

Cytogenetic location: 5q12.1 Genomic coordinates (GRCh38): 5:62,387,254-62,403,905 (from NCBI)

This gene has 18 transcripts (splice variants), 212 orthologues and 2 paralogues. Ubiquitous expression in urinary bladder (RPKM 12.5), lymph node (RPKM 11.7) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种甲基转移酶，负责 18S rRNA 解码位点附近相邻腺苷的二甲基化。编码的蛋白质对于核糖体生物发生至关重要，尽管其催化活性不参与该过程。该蛋白质的酵母直系同源物在细胞质中起作用，而该蛋白质在细胞核中起作用。[RefSeq 提供，2017 年 1 月]

The protein encoded by this gene is a methyltransferase that is responsible for dimethylation of adjacent adenosines near the 18S rRNA decoding site. The encoded protein is essential for ribosome biogenesis, although its catalytic activity is not involved in the process. The yeast ortholog of this protein functions in the cytoplasm while this protein functions in the nucleus. [provided by RefSeq, Jan 2017]

DIMT1 基因产物(3)

mRNA Protein Name
NM_001348076.2 NP_001335005.1 probable dimethyladenosine transferase isoform 2
NM_001348077.2 NP_001335006.1 probable dimethyladenosine transferase isoform 3
NM_014473.4 NP_055288.1 probable dimethyladenosine transferase isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity IMP
IMP: 通过突变表型推断
25851604 GOA
enables rRNA (adenine-N6,N6-)-dimethyltransferase activity EXP
EXP: 通过实验结果推断
25851604 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of rRNA processing IMP
IMP: 通过突变表型推断
25851604 GOA
involved in rRNA methylation IMP
IMP: 通过突变表型推断
25851604 GOA
involved in ribosomal small subunit biogenesis IDA
IDA: 通过直接分析推断
34516797 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleolus IDA
IDA: 通过直接分析推断
25851604 GOA
part of small-subunit processome IDA
IDA: 通过直接分析推断
34516797 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DIMT1 蛋白结构

RrnaAD

RrnaAD: Ribosomal RNA adenine dimethylase (31 - 263)

  • 0
  • 100
  • 200
  • 313 a.a.
蛋白主名 其他名称

probable dimethyladenosine transferase

18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase

关联疾病

疾病名称 别名
Localized Osteosarcoma

Localised Osteogenic Sarcoma

Localised Osteosarcoma

Localized Osteogenic Sarcoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03768 DIMT1 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus DIMT1 VGNC VGNC:28065
Macaca mulatta DIMT1 VGNC VGNC:71818
Felis catus DIMT1 VGNC VGNC:61491
Rattus norvegicus DIMT1 RGD RGD:1311752
Canis familiaris DIMT1 VGNC VGNC:52127
Mus musculus DIMT1 MGD MGI:1913504
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