2. Gene
  3. Timp2 - TIMP metallopeptidase inhibitor 2 Gene

Timp2 - TIMP metallopeptidase inhibitor 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 29543 | 基因类型: protein coding

关于 Timp2

功能概要

Enables Integrin binding activity and metalloendopeptidase inhibitor activity. Involved in several processes, including positive regulation of Adenylate Cyclase activity; positive regulation of neuron differentiation; and regulation of intracellular signal transduction. Located in several cellular components, including cell surface; growth cone; and neuronal cell body. Used to study portal hypertension. Biomarker of cardiomyopathy; congestive heart failure; and intracranial aneurysm. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2). [provided by Alliance of Genome Resources, Apr 2022]

Timp2 基因产物(1)

mRNA Protein Name
NM_021989.3 NP_068824.1 metalloproteinase inhibitor 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables integrin binding IPI
IPI: 通过物理相互作用推断
15901773 RGD
enables metalloendopeptidase inhibitor activity IMP
IMP: 通过突变表型推断
15901773 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of Ras protein signal transduction IDA
IDA: 通过直接分析推断
15901773 RGD
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
15901773 RGD
involved in negative regulation of mitotic cell cycle IDA
IDA: 通过直接分析推断
15901773 RGD
involved in negative regulation of proteolysis IMP
IMP: 通过突变表型推断
17532789 RGD
involved in positive regulation of MAPK cascade IDA
IDA: 通过直接分析推断
15901773 RGD
involved in positive regulation of adenylate cyclase activity IMP
IMP: 通过突变表型推断
15901773 RGD
involved in positive regulation of neuron differentiation IDA
IDA: 通过直接分析推断
15901773 RGD
involved in regulation of Rap protein signal transduction IDA
IDA: 通过直接分析推断
15901773 RGD
involved in response to cytokine IEP
IEP: 通过表达模式推断
17822627 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
17491697 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
15901773 RGD
located in extracellular space IDA
IDA: 通过直接分析推断
15901773 RGD
located in growth cone IDA
IDA: 通过直接分析推断
15901773 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
15901773 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

metalloproteinase inhibitor 2

TIMP-2

tissue inhibitor of metalloproteinase 2

tissue inhibitor of metalloproteinases 2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14539 TIMP2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17383 Timp2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23838 Timp2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Timp2 NCBI NCBI:7077
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