GZMA - granzyme A Gene

中文名称：颗粒酶 A

种属: Homo sapiens

同用名: HFSP; CTLA3

关于 GZMA

功能概要

溶细胞性 T 淋巴细胞 (CTL) 和自然杀伤 (NK) 细胞具有识别、结合和裂解特定靶细胞的非凡能力。人们认为它们通过裂解表面带有“非自身”抗原的细胞来保护宿主，这些抗原通常是细胞内病原体感染产生的肽或蛋白质。此处描述的蛋白质是一种 T 细胞和自然杀伤细胞特异性丝氨酸蛋白酶，可作为细胞毒性 T 淋巴细胞和自然杀伤细胞裂解靶细胞所必需的常见成分。[RefSeq 提供，2008 年 7 月]

Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually Peptides or proteins resulting from Infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq, Jul 2008]