2. Gene
  3. Mthfr - methylenetetrahydrofolate reductase Gene

Mthfr - methylenetetrahydrofolate reductase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 362657 | 基因类型: protein coding

关于 Mthfr

功能概要

Enables NADP binding activity; flavin adenine dinucleotide binding activity; and methylenetetrahydrofolate reductase (NAD(P)H) activity. Involved in several processes, including homocysteine metabolic process; response to interleukin-1; and response to vitamin. Located in cytosol and synapse. Biomarker of hyperthyroidism; hypothyroidism; and liver benign neoplasm. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cardiovascular system disease (multiple); hematologic Cancer (multiple); and kidney failure (multiple). Orthologous to human MTHFR (methylenetetrahydrofolate reductase). [provided by Alliance of Genome Resources, Apr 2022]

Mthfr 基因产物(5)

mRNA Protein Name
XM_006239414.4 XP_006239476.1 methylenetetrahydrofolate reductase isoform X3
XM_006239416.2 XP_006239478.1 methylenetetrahydrofolate reductase isoform X4
XM_006239417.2 XP_006239479.1 methylenetetrahydrofolate reductase isoform X4
XM_006239413.4 XP_006239475.1 methylenetetrahydrofolate reductase isoform X2
XM_342975.8 XP_342976.3 methylenetetrahydrofolate reductase isoform X1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NADP binding IDA
IDA: 通过直接分析推断
11730351 RGD
enables flavin adenine dinucleotide binding IDA
IDA: 通过直接分析推断
11730351 RGD
enables methylenetetrahydrofolate reductase (NAD(P)H) activity IDA
IDA: 通过直接分析推断
11730351 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in S-adenosylmethionine metabolic process IEP
IEP: 通过表达模式推断
1201245 RGD
involved in homocysteine metabolic process IEP
IEP: 通过表达模式推断
18726220 RGD
involved in response to amino acid IEP
IEP: 通过表达模式推断
737254 RGD
involved in response to folic acid IEP
IEP: 通过表达模式推断
15313378 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
15845641 RGD
involved in response to interleukin-1 IEP
IEP: 通过表达模式推断
18726220 RGD
involved in response to vitamin B2 IEP
IEP: 通过表达模式推断
3676170 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
3088464 RGD
involved in tetrahydrofolate metabolic process IDA
IDA: 通过直接分析推断
11730351 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

methylenetetrahydrofolate reductase

5,10-methylenetetrahydrofolate reductase (NADPH)

methylenetetrahydrofolate reductase (NAD(P)H)

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08778 MTHFR Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20057 Mthfr Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26561 Mthfr Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mthfr NCBI NCBI:4524
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