SLURP2 - secreted LY6/PLAUR domain containing 2 Gene

中文名称：含分泌的 LY6/PLAUR 结构域 2

种属: Homo sapiens

同用名: SLURP-2

关于 SLURP2

功能概要

该基因编码 Ly6/uPAR (LU) 蛋白质超家族的一个新的分泌成员，其中包含独特的三指 LU 结构域。该基因主要在上皮细胞中表达，包括皮肤和角质形成细胞，并且在银屑病皮损中上调，表明其参与银屑病的病理生理学。已发现该基因的可变剪接转录物变体。来自邻近上游基因 (LYNX1) 的通读转录生成天然存在的转录本 (LYNX1-SLURP2) ，该转录本编码一种融合蛋白，该融合蛋白由与每个单独基因产物共享同一性的序列组成。[RefSeq 提供，2017 年 9 月]

This gene encodes a novel, secreted member of the Ly6/uPAR (LU) superfamily of proteins containing the unique three-finger LU domain. This gene is mainly expressed in epithelial cells, including skin and keratinocytes, and is up-regulated in psoriatic skin lesions, suggesting its involvement in the pathophysiology of psoriasis. Alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (LYNX1) generates naturally-occurring transcripts (LYNX1-SLURP2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Sep 2017]