2. Gene
  3. Otulin - OTU deubiquitinase with linear linkage specificity Gene

Otulin - OTU deubiquitinase with linear linkage specificity Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: m3Sapc; Fam105b; m7-1Sapc

基因 ID: 432940 | 基因类型: protein coding

关于 Otulin

功能概要

Enables thiol-dependent Deubiquitinase. Involved in several processes, including negative regulation of NF-kappaB transcription factor activity; protein linear deubiquitination; and regulation of signal transduction. Located in cytoplasm. Part of LUBAC complex. Is expressed in several structures, including branchial arch; cardiovascular system; genitourinary system; gut; and hemolymphoid system. Human ortholog(s) of this gene implicated in otulipenia. Orthologous to human OTULIN (OTU Deubiquitinase with linear linkage specificity). [provided by Alliance of Genome Resources, Apr 2022]

Otulin 基因产物(1)

mRNA Protein Name
NM_001013792.2 NP_001013814.2 ubiquitin thioesterase otulin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cysteine-type deubiquitinase activity IDA
IDA: 通过直接分析推断
23708998 MGI
enables cysteine-type peptidase activity IMP
IMP: 通过突变表型推断
23708998 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
27523608 MGI
involved in negative regulation of inflammatory response IMP
IMP: 通过突变表型推断
27523608 MGI
involved in protein linear deubiquitination IDA
IDA: 通过直接分析推断
23708998 MGI
involved in regulation of canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
23708998 MGI
involved in regulation of tumor necrosis factor-mediated signaling pathway IMP
IMP: 通过突变表型推断
27523608 MGI
involved in sprouting angiogenesis IMP
IMP: 通过突变表型推断
23708998 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of LUBAC complex IDA
IDA: 通过直接分析推断
23708998 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
23708998 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ubiquitin thioesterase otulin

OTU domain-containing deubiquitinase with linear linkage specificity

deubiquitinating enzyme otulin

family with sequence similarity 105, member B

gumby

protein FAM105B

ubiquitin thioesterase Gumby

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09878 OTULIN Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS19070 Otulin Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS25560 Otulin Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Otulin NCBI NCBI:90268
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