MIR375 - microRNA 375 Gene

中文名称：微小 RNA 375

种属: Homo sapiens

同用名: MIRN375; mir-375; miRNA375; hsa-mir-375

基因 ID: 494324 | 基因类型: ncRNA

关于 MIR375

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:219,001,645-219,001,708 (from NCBI)

This gene has 1 transcript (splice variant) and 124 orthologues.

功能概要

微小 RNA (miRNA) 是短的 (20-24 nt) 非编码 RNA，通过影响 mRNA 的稳定性和翻译，参与多细胞生物中基因表达的转录后调控。 miRNA 由 RNA 聚合酶 II 转录，作为加帽和聚腺苷酸化初级转录物 (pri-miRNA) 的一部分，可以是蛋白质编码或非编码的。初级转录物被 Drosha 核糖核酸酶 III 酶切产生大约 70 nt 的茎环前体 miRNA (pre-miRNA) ，它被细胞质 Dicer 核糖核酸酶进一步切割以产生成熟的 miRNA 和反义 miRNA 星 (miRNA * ) 产品。成熟的 miRNA 被整合到 RNA 诱导的沉默复合体 (RISC) 中，它通过与 miRNA 的不完美碱基配对识别靶 mRNA，最常见的结果是靶 mRNA 的翻译抑制或不稳定。 RefSeq 代表预测的 MicroRNA 茎环。[RefSeq 提供，2009 年 9 月]

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III Enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

基因本体论

生物过程

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of sprouting angiogenesis	IGI IGI: 通过遗传相互作用推断	26235810	GOA
involved in positive regulation of endothelial cell apoptotic process	IGI IGI: 通过遗传相互作用推断	26235810	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

关联疾病

疾病名称

别名

Lung Cancer Susceptibility 3

Lung Adenocarcinoma	Adenocarcinoma Of Lung
LNCR3	Adenocarcinoma Of Lung, Susceptibility To
Bronchogenic Lung Adenocarcinoma	Nonsmall Cell Adenocarcinoma
Adenocarcinoma Lung	Lung Adenocarcinomas
Non-Small Cell Adenocarcinoma

Diabetes Mellitus

Diabetes

Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck	HNSCC
Head And Neck Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Lip
Squamous Cell Carcinoma, Head And Neck, Somatic	Carcinoma Of The Head And Neck
Squamous Cell Carcinomas Of Head And Neck	Scchn
Squamous Cell Carcinoma Of The Hypopharynx	Squamous Cell Carcinoma Of The Oropharynx
Squamous Cell Carcinoma Of Salivary Glands	Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses
Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses	Squamous Cell Carcinoma Of The Oral Cavity
Squamous Cell Carcinoma Of The Lip	Carcinoma, Squamous Cell Of Head And Neck
Lip Squamous Cell Carcinoma	Carcinoma, Squamous Cell, Head And Neck
Salivary Gland Squamous Cell Carcinoma	Cancer Of Head And Neck
Squamous Cell Carcinoma Of Oropharynx Nos

Esophageal Cancer

Esophageal Carcinoma	Carcinoma Of Esophagus
Esophageal Squamous Cell Carcinoma, Somatic	Esophageal Carcinoma, Somatic
Esophagus Cancer	Gastric Cardia Adenocarcinoma
Esophageal Neoplasms	Esophageal Cancer, Somatic
Cancer Of Esophagus	Cancer Of Oesophagus
Carcinoma Of Oesophagus	Ca Lower Third Oesophagus
Ca Middle Third Oesophagus	Malignant Neoplasm Of Distal Third Of Esophagus
Malignant Neoplasm Of Lower Third Of Oesophagus	Malignant Neoplasm Of Middle Third Of Oesophagus
Malignant Neoplasm Of Proximal Third Of Esophagus	Malignant Neoplasm Of Upper Third Esophagus
Malignant Tumor Of Abdominal Esophagus	Malignant Tumor Of Distal Third Of Esophagus
Malignant Tumor Of Proximal Third Of Esophagus	Malignant Tumor Of The Middle Third Of The Esophagus
ESCR	Aerodigestive Tract Cancer
Escc	Esophageal Squamous Cell Carcinoma
Cancer, Esophageal	Malignant Neoplasm Of Esophagus
Squamous Cell Carcinoma Of Esophagus	Malignant Neoplasm Of Middle Third Of Esophagus

Pancreatic Ductal Adenocarcinoma

Ductal Adenocarcinoma Of The Pancreas

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Maxillary Sinus Cancer

Malignant Neoplasm Of Antrum	Malignant Tumor Of The Maxillary Sinus
Maxillary Sinus Carcinoma	Cancer Of Maxillary Sinus
Maxillary Sinus Neoplasms

Maxillary Sinus Squamous Cell Carcinoma

Epidermoid Carcinoma Of The Maxillofacial Sinus

Cataract 30

Cataract 30 Pulverulent	Cataract Coppock-Like
Ctrct30	Dusty Cataract
Cataract, Type 30

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	纯度	是否罕见病
HY-R00834	hsa-miR-375-3p mimic	/	否
HY-R00834A	hsa-miR-375-3p agomir	/	否
HY-R00835	hsa-miR-375-5p mimic	/	否
HY-R00835A	hsa-miR-375-5p agomir	/	否
HY-R03106	mmu-miR-375-5p mimic	/	否
HY-R03106A	mmu-miR-375-5p agomir	/	否
HY-RI00834	hsa-miR-375-3p inhibitor	/	否
HY-RI00834A	hsa-miR-375-3p antagomir	/	否
HY-RI00835	hsa-miR-375-5p inhibitor	/	否
HY-RI00835A	hsa-miR-375-5p antagomir	/	否
HY-RI03106	mmu-miR-375-5p inhibitor	/	否
HY-RI03106A	mmu-miR-375-5p antagomir	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	MIR375	MGD	MGI:3619376
Rattus norvegicus	MIR375	RGD	RGD:2325360

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MIR375 - microRNA 375 Gene

关于 MIR375

功能概要

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MIR375 - microRNA 375 Gene

关于 MIR375

功能概要

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

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Q

S

T

X

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