2. Gene
  3. Gjc2 - gap junction protein, gamma 2 Gene

Gjc2 - gap junction protein, gamma 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Cx47; Gja12

基因 ID: 497913 | 基因类型: protein coding

关于 Gjc2

功能概要

Predicted to enable gap junction channel activity involved in cell communication by electrical coupling. Involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; nervous system development; and positive regulation of calcium ion transmembrane transport. Located in several cellular components, including paranode region of axon; perikaryon; and proximal neuron projection. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in hereditary lymphedema IC; hereditary spastic paraplegia 44; hypomyelinating leukodystrophy 2; and lymphedema. Orthologous to human GJC2 (Gap Junction Protein gamma 2). [provided by Alliance of Genome Resources, Apr 2022]

Gjc2 基因产物(1)

mRNA Protein Name
NM_001100784.1 NP_001094254.1 gap junction gamma-2 protein
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of G1/S transition of mitotic cell cycle IMP
IMP: 通过突变表型推断
28278052 RGD
involved in positive regulation of calcium ion transmembrane transport IMP
IMP: 通过突变表型推断
28278052 RGD
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
28278052 RGD
involved in positive regulation of oligodendrocyte progenitor proliferation IMP
IMP: 通过突变表型推断
28278052 RGD
involved in regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
28278052 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in gap junction IDA
IDA: 通过直接分析推断
16203097 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
16203097 RGD
located in paranode region of axon IDA
IDA: 通过直接分析推断
16203097 RGD
located in perikaryon IDA
IDA: 通过直接分析推断
15293232 RGD
located in proximal neuron projection IDA
IDA: 通过直接分析推断
15293232 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

gap junction gamma-2 protein

connexin-47

gap junction alpha-12 protein

gap junction membrane channel protein alpha 12

gap junction protein, alpha 12

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05453 GJC2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gjc2 NCBI NCBI:57165
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