2. Gene
  3. CXXC5 - CXXC finger protein 5 Gene

CXXC5 - CXXC finger protein 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CXXC 指蛋白 5

种属: Homo sapiens

同用名: CF5; WID; RINF; HSPC195

基因 ID: 51523 | 基因类型: protein coding

关于 CXXC5

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:139,647,299-139,683,882 (from NCBI)

This gene has 16 transcripts (splice variants), 206 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 19.6), kidney (RPKM 19.4) and 24 other tissues.

功能概要

该基因编码的蛋白质是类视黄醇诱导核蛋白，含有 CXXC 型锌指基序。编码的蛋白质参与骨髓细胞生成，是 DNA 损伤诱导的 p53 激活所必需的，调节 C2C12 成肌细胞向肌细胞的分化，并负向调节皮肤伤口愈合。已发现该基因的几种转录变体编码相同的蛋白质。[RefSeq 提供，2015 年 11 月]

The protein encoded by this gene is a retinoid-inducible nuclear protein containing a CXXC-type zinc finger motif. The encoded protein is involved in myelopoiesis, is required for DNA damage-induced p53 activation, regulates the differentiation of C2C12 myoblasts into myocytes, and negatively regulates cutaneous wound healing. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]

CXXC5 基因产物(14)

mRNA Protein Name
NM_001317199.2 NP_001304128.1 CXXC-type zinc finger protein 5
NM_001317200.2 NP_001304129.1 CXXC-type zinc finger protein 5
NM_001317201.2 NP_001304130.1 CXXC-type zinc finger protein 5
NM_001317202.2 NP_001304131.1 CXXC-type zinc finger protein 5
NM_001317203.2 NP_001304132.1 CXXC-type zinc finger protein 5
NM_001317204.2 NP_001304133.1 CXXC-type zinc finger protein 5
NM_001317205.2 NP_001304134.1 CXXC-type zinc finger protein 5
NM_001317206.2 NP_001304135.1 CXXC-type zinc finger protein 5
NM_001317207.2 NP_001304136.1 CXXC-type zinc finger protein 5
NM_001317208.2 NP_001304137.1 CXXC-type zinc finger protein 5
NM_001317209.2 NP_001304138.1 CXXC-type zinc finger protein 5
NM_001317210.2 NP_001304139.1 CXXC-type zinc finger protein 5
NM_001317211.2 NP_001304140.1 CXXC-type zinc finger protein 5
NM_016463.9 NP_057547.5 CXXC-type zinc finger protein 5
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor binding IDA
IDA: 通过直接分析推断
23303788 GOA
enables methyl-CpG binding IDA
IDA: 通过直接分析推断
29276034 GOA
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
23303788 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
29276034 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
23303788 GOA
involved in regulation of generation of precursor metabolites and energy IDA
IDA: 通过直接分析推断
23303788 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CXXC5 蛋白结构

zf-CXXC

zf-CXXC: CXXC zinc finger domain (257 - 296)

  • 0
  • 100
  • 200
  • 300
  • 322 a.a.
蛋白主名 其他名称

CXXC-type zinc finger protein 5

CXXC finger 5 protein

关联疾病

疾病名称 别名
Astroblastoma, Mn1-Altered

Cns High-Grade Neuroepithelial Tumors With Mn1 Alteration
Arthrogryposis, Distal, Type 4

Distal Arthrogryposis Type 4

DA4

Daiid

Arthrogryposis-Severe Scoliosis Syndrome

Distal Arthrogryposis Type Iid

Arthrogryposis With Severe Scoliosis

Arthrogryposis, Distal, Type Iid
Astroblastoma

Cerebral Astroblastoma
Cardiomyopathy, Familial Hypertrophic, 17

Hypertrophic Cardiomyopathy 17

CMH17

Cardiomyopathy, Hypertrophic, 17

Cardiomyopathy Familial Hypertrophic 17

Cardiomyopathy, Familial Hypertrophic 17

Cardiomyopathy, Hypertrophic, Familial, Type 17
Spondyloepiphyseal Dysplasia, Kimberley Type

SEDK

Spondyloepiphyseal Dysplasia Kimberley Type

Spondyloepiphyseal Dysplasia Type Kimberley

Dysplasia, Spondyloepiphyseal, Kimberley Type
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-131447 KY19382 98.0% 否
HY-124156A KY-02327 acetate Inhibitor 99.24% 否
HY-131448 A3334 99.64% 否
HY-124156 KY-02327 Inhibitor / 否
HY-178227 KY19334 Inhibitor / 否
HY-P11112 PTD-DBM Activator / 否
HY-RS03415 CXXC5 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18171 Cxxc5 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24645 Cxxc5 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta CXXC5 VGNC VGNC:71594
Canis familiaris CXXC5 VGNC VGNC:39754
Bos taurus CXXC5 VGNC VGNC:27860
Felis catus CXXC5 VGNC VGNC:61305
Rattus norvegicus CXXC5 RGD RGD:1359466
Mus musculus CXXC5 MGD MGI:1914643
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