DUOX1 - dual oxidase 1 Gene

中文名称：双氧化酶 1

种属: Homo sapiens

同用名: LNOX1; THOX1; NOXEF1

基因 ID: 53905 | 基因类型: protein coding

关于 DUOX1

Cytogenetic location: 15q21.1 Genomic coordinates (GRCh38): 15:45,129,994-45,165,574 (from NCBI)

This gene has 13 transcripts (splice variants), 94 orthologues and 6 paralogues. Biased expression in skin (RPKM 27.3), thyroid (RPKM 26.8) and 8 other tissues.

功能概要

该基因编码的蛋白质是一种糖蛋白，是 NADPH 氧化酶家族的成员。甲状腺激素的合成由位于甲状腺滤泡细胞顶膜的蛋白质复合物催化。该复合物包含碘化物转运蛋白、甲状腺过氧化物酶和过氧化物生成系统，该系统包括由该基因和类似的 DUOX2 基因编码的蛋白质。这种蛋白质被称为双氧化酶，因为它同时具有过氧化物酶同源结构域和 gp91phox 结构域。这种蛋白质产生过氧化氢，从而在甲状腺过氧化物酶、乳过氧化物酶的活性和粘膜表面的乳过氧化物酶介导的抗菌防御中发挥作用。已针对该基因描述了编码相同蛋白质的两个可变剪接转录物变体。[RefSeq 提供，2012 年 7 月]

The protein encoded by this gene is a glycoprotein and a member of the NADPH Oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]

DUOX1 基因产物(2)

mRNA	Protein	Name
NM_017434.5	NP_059130.2	dual oxidase 1 precursor
NM_175940.3	NP_787954.1	dual oxidase 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	19339556	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cuticle development	IMP IMP: 通过突变表型推断	11514595	GOA
involved in cytokine-mediated signaling pathway	IDA IDA: 通过直接分析推断	16111680	GOA
involved in hydrogen peroxide biosynthetic process	IGI IGI: 通过遗传相互作用推断	19339556	GOA
involved in positive regulation of cell motility	IGI IGI: 通过遗传相互作用推断	19339556	GOA
involved in positive regulation of wound healing	IGI IGI: 通过遗传相互作用推断	19339556	GOA
involved in response to cAMP	IDA IDA: 通过直接分析推断	15062544	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell leading edge	IGI IGI: 通过遗传相互作用推断	19339556	GOA
located in cell surface	IGI IGI: 通过遗传相互作用推断	22814254	GOA
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	19339556	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	19339556	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DUOX1 蛋白结构

An_peroxidase

EF-hand_7

Ferric_reduct

FAD_binding_8

NAD_binding_6

0
300
600
900
1200
1551 a.a.

蛋白主名

其他名称

dual oxidase 1

NADPH thyroid oxidase 1

DUOX1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	DUOX1	Q9NRD9	DUOXA1	Homo sapiens	Q1HG43	GMS	33420071
种属内	DUOX1	Q9NRD9	DUOXA1	Homo sapiens	Q1HG43	UV-VIS	33420071
种属内	DUOX1	Q9NRD9	DUOXA1	Homo sapiens	Q1HG43	3D-EM	33420071

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Congenital Hypothyroidism

Cretinism	Neonatal Hypothyroidism
Ch	Cht
Congenital Myxedema	Myxedema, Congenital
Endemic Cretinism	Congenital Iodine-Deficiency Syndrome
Fetal Iodine Deficiency Syndrome	Congenital Iodine-Deficiency Hypothyroidism Nos

Granulomatous Disease, Chronic, Autosomal Recessive, 4

Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Negative	Cyba Deficiency
CGD4	Cgd Due To Deficiency Of The Alpha Subunit Of Cytochrome B
Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Negative	Cgd, Autosomal Recessive Cytochrome B-Negative
Chronic Granulomatous Disease 4, Autosomal Recessive	Autosomal Recessive Chronic Granulomatous Disease 4
Autosomal Recessive Cytochrome B-Negative Cgd	Chronic Granulomatous Disease Due To Deficiency Of Cyba
Cgd Due To Deficiency Of Alpha Subunit Of Cytochrome B	Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Negative
Granulomatous Disease, Chronic, Cytochrome-B-Negative, Autosomal Recessive

Phagocyte Bactericidal Dysfunction

Phagocytic Dysfunction

Hypothyroidism

Thyroid Diseases	Thyroid Disease
Thyroid Deficiency	Thyroid Insufficiency
Dysfunction Thyroid	Thyroid Dysfunction

Granulomatous Disease, Chronic, X-Linked

CGDX	Chronic Granulomatous Disease, X-Linked
X-Linked Chronic Granulomatous Disease	Cgd
Cytochrome B-Negative Granulomatous Disease, Chronic, X-Linked	Cdgx
X-Linked Chronic Cytochrome B-Negative Granulomatous Disease	Chronic Granulomatous Disease Cytochrome B-Negative X-Linked
Chronic Granulomatous Disease Cytochrome B-Positive X-Linked	Granulomatous Disease, Chronic, X-Linked, Variant

Chronic Granulomatous Disease

Cgd	Granulomatous Disease, Chronic
Autosomal Recessive Chronic Granulomatous Disease	X-Linked Chronic Granulomatous Disease
Bridges-Good Syndrome	Congenital Dysphagocytosis
Quie Syndrome	Chronic Septic Granulomatosis
Chronic Granulomatous Disorder	Granulomatous Disease Chronic
Granulomatous Disease, Chronic, X-Linked

Lung Disease

Lung Diseases	Disorder Of Lung
Abnormality Of The Lung

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-174818	NOX5-IN-2	Inhibitor	/	否
HY-174817	NOX5-IN-1	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	DUOX1	VGNC	VGNC:28241
Canis familiaris	DUOX1	VGNC	VGNC:40120
Rattus norvegicus	DUOX1	RGD	RGD:628760
Macaca mulatta	DUOX1	VGNC	VGNC:72009
Mus musculus	DUOX1	MGD	MGI:2139422
Felis catus	DUOX1	VGNC	VGNC:61653

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DUOX1 - dual oxidase 1 Gene

关于 DUOX1

功能概要

DUOX1 基因产物(2)

DUOX1 蛋白结构

DUOX1 蛋白互作信息

关联疾病

直系同源

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DUOX1 - dual oxidase 1 Gene

关于 DUOX1

功能概要

DUOX1 基因产物(2)

DUOX1 蛋白结构

DUOX1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z