1. Gene
  2. NLE1 - notchless homolog 1 Gene

NLE1 - notchless homolog 1 Gene

中文名称:无缺口同系物 1

种属: Homo sapiens

同用名: NLE

基因 ID: 54475 | 基因类型: protein coding

关于 NLE1

This gene has 7 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in testis (RPKM 6.4), ovary (RPKM 4.9) and 25 other tissues.

功能概要

预计参与 Notch 信号通路和核糖体大亚基组装。预计在几个过程的上游或内部起作用,包括脊索动物胚胎发育;造血干细胞稳态;和信号转导的调节。位于核仁和核质中。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to be involved in Notch signaling pathway and ribosomal large subunit assembly. Predicted to act upstream of or within several processes, including chordate embryonic development; hematopoietic stem cell homeostasis; and regulation of signal transduction. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NLE1 基因产物(2)

mRNA Protein Name
NM_001014445.2 NP_001014445.1 notchless protein homolog 1 isoform b
NM_018096.5 NP_060566.2 notchless protein homolog 1 isoform a
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
33961781 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

NLE1 蛋白结构

NLE

NLE: NLE (NUC135) domain (17 - 77)

WD40

WD40: WD domain, G-beta repeat (105 - 142)

WD40

WD40: WD domain, G-beta repeat (148 - 184)

WD40

WD40: WD domain, G-beta repeat (192 - 232)

WD40

WD40: WD domain, G-beta repeat (236 - 272)

WD40

WD40: WD domain, G-beta repeat (279 - 357)

WD40

WD40: WD domain, G-beta repeat (363 - 400)

WD40

WD40: WD domain, G-beta repeat (404 - 442)

WD40

WD40: WD domain, G-beta repeat (452 - 483)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 485 a.a.
蛋白主名 其他名称

notchless protein homolog 1

Notchless gene homolog

关联疾病

疾病名称 别名
Pasteurellosis

Pasteurella Infection

Pasteurella Infections

Pasteurella Infectious Disease

Shipping Fever

Transport Fever

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus NLE1 VGNC VGNC:32109
Canis familiaris NLE1 VGNC VGNC:43838
Felis catus NLE1 VGNC VGNC:63820
Macaca mulatta NLE1 VGNC VGNC:75217
Rattus norvegicus NLE1 RGD RGD:1308301
Mus musculus NLE1 MGD MGI:2429770