2. Gene
  3. NEIL3 - nei like DNA glycosylase 3 Gene

NEIL3 - nei like DNA glycosylase 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：nei 样 DNA 糖基化酶 3

种属: Homo sapiens

同用名: FGP2; FPG2; NEI3; ZGRF3; hFPG2; hNEI3

基因 ID: 55247 | 基因类型: protein coding

关于 NEIL3

Cytogenetic location: 4q34.3 Genomic coordinates (GRCh38): 4:177,309,874-177,371,268 (from NCBI)

This gene has 2 transcripts (splice variants), 185 orthologues and 2 paralogues. Biased expression in bone marrow (RPKM 2.5), lymph node (RPKM 1.9) and 13 other tissues.

功能概要

NEIL3 属于一类与细菌 Fpg/Nei 家族同源的 DNA 糖基化酶。这些糖基化酶通过切割被活性氧物质破坏的碱基并通过相关的裂解酶反应引入 DNA 链断裂来启动碱基切除修复的第一步 (Bandaru 等人，2002 [PubMed 12509226]) 。[OMIM 提供，2008 年 3 月]

NEIL3 belongs to a class of DNA glycosylases homologous to the Bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving Bases damaged by Reactive Oxygen Species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM, Mar 2008]

NEIL3 基因产物(1)

mRNA Protein Name
NM_018248.3 NP_060718.3 endonuclease 8-like 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA N-glycosylase activity IDA
IDA: 通过直接分析推断
23755964 GOA
enables DNA-(apurinic or apyrimidinic site) endonuclease activity IDA
IDA: 通过直接分析推断
19170771 GOA
enables single-stranded DNA binding IDA
IDA: 通过直接分析推断
19170771 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in base-excision repair IDA
IDA: 通过直接分析推断
23755964 GOA
involved in single strand break repair IDA
IDA: 通过直接分析推断
19170771 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
12433996 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NEIL3 蛋白结构

H2TH

H2TH: Formamidopyrimidine-DNA glycosylase H2TH domain (165 - 227)

zf-RanBP

zf-RanBP: Zn-finger in Ran binding protein and others (317 - 345)

zf-GRF

zf-GRF: GRF zinc finger (506 - 548)

zf-GRF

zf-GRF: GRF zinc finger (552 - 595)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 605 a.a.
蛋白主名 其他名称

endonuclease 8-like 3

DNA glycosylase FPG2

关联疾病

疾病名称 别名
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09189 NEIL3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22676 Neil3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS29190 Neil3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus NEIL3 VGNC VGNC:31990
Mus musculus NEIL3 MGD MGI:2384588
Macaca mulatta NEIL3 VGNC VGNC:75248
Rattus norvegicus NEIL3 RGD RGD:1310562
Canis familiaris NEIL3 VGNC VGNC:43728
Felis catus NEIL3 VGNC VGNC:63768
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