2. Gene
  3. PI4K2B - phosphatidylinositol 4-kinase type 2 beta Gene

PI4K2B - phosphatidylinositol 4-kinase type 2 beta Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷脂酰肌醇 4-激酶 2 型

种属: Homo sapiens

同用名: PIK42B; PI4KIIB

基因 ID: 55300 | 基因类型: protein coding

关于 PI4K2B

Cytogenetic location: 4p15.2 Genomic coordinates (GRCh38): 4:25,234,033-25,279,204 (from NCBI)

This gene has 2 transcripts (splice variants), 207 orthologues and 1 paralogue. Ubiquitous expression in duodenum (RPKM 18.2), small intestine (RPKM 15.4) and 25 other tissues.

功能概要

该基因编码 II 型 PI4 激酶蛋白家族的成员。编码的蛋白质主要是胞质的，与其他蛋白质家族成员一起参与整体 PI4 激酶活性。该蛋白参与早期 T 细胞活化。[RefSeq 提供，2016 年 12 月]

This gene encodes a member of the type II PI4 kinase protein family. The encoded protein is primarily cytosolic and contributes to overall PI4-kinase activity along with Other protein family members. This protein is involved in early T cell activation. [provided by RefSeq, Dec 2016]

PI4K2B 基因产物(1)

mRNA Protein Name
NM_018323.4 NP_060793.2 phosphatidylinositol 4-kinase type 2-beta
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 1-phosphatidylinositol 4-kinase activity IDA
IDA: 通过直接分析推断
11923287 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in phosphatidylinositol phosphate biosynthetic process IDA
IDA: 通过直接分析推断
11923287 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi membrane IDA
IDA: 通过直接分析推断
11923287 GOA
located in cytosol IDA
IDA: 通过直接分析推断
12324459 GOA
located in early endosome membrane IDA
IDA: 通过直接分析推断
11923287 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
12324459 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
12324459 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PI4K2B 蛋白结构

PI3_PI4_kinase

PI3_PI4_kinase: Phosphatidylinositol 3- and 4-kinase (131 - 434)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 481 a.a.
蛋白主名 其他名称

phosphatidylinositol 4-kinase type 2-beta

PI4KII-BETA

关联疾病

疾病名称 别名
Macrocephaly/Autism Syndrome

Macrocephaly-Autism Syndrome

Macrocephaly-Intellectual Disability-Autism Syndrome

MCEPHAS
Developmental And Epileptic Encephalopathy 53

DEE53

Epileptic Encephalopathy, Early Infantile, 53

Eiee53

Developmental And Epileptic Encephalopathy, 53

Early Infantile Epileptic Encephalopathy 53
Parkinson Disease 20, Early-Onset

Early-Onset Parkinson Disease 20

PARK20

Parkinson'S Disease 20

Early-Onset Parkinson'S Disease 20

Parkinson Disease, Type 20, Early-Onset
Post-Vaccinal Encephalitis

Encephalitis Following Immunization Procedures

Postvaccinal Encephalomyelitis

Encephalomyelitis, Acute Disseminated
Adams-Oliver Syndrome

Adams Oliver Syndrome

Aos

Congenital Scalp Defects With Distal Limb Reduction Anomalies

Aplasia Cutis Congenita With Terminal Transverse Limb Defects

Congenital Scalp Defects With Distal Limb Anomalies

Limb, Scalp And Skull Defects

Limb Scalp And Skull Defects

Absence Defect Of Limbs, Scalp, And Skull
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10465 PI4K2B Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20189 Pi4k2b Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26693 Pi4k2b Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PI4K2B VGNC VGNC:110547
Bos taurus PI4K2B VGNC VGNC:97298
Felis catus PI4K2B VGNC VGNC:82521
Mus musculus PI4K2B MGD MGI:1914323
Canis familiaris PI4K2B VGNC VGNC:97213
Rattus norvegicus PI4K2B RGD RGD:1359515
Others PI4K2B NCBI
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