2. Gene
  3. Tsc1 - TSC complex subunit 1 Gene

Tsc1 - TSC complex subunit 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 60445 | 基因类型: protein coding

关于 Tsc1

功能概要

Enables GTPase activating protein binding activity and protein N-terminus binding activity. Involved in several processes, including cellular response to oxygen-glucose deprivation; negative regulation of GTPase activity; and regulation of macroautophagy. Located in several cellular components, including cytosol; growth cone; and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study obesity. Human ortholog(s) of this gene implicated in intellectual disability; lymphangioleiomyomatosis; tuberous sclerosis; and tuberous sclerosis 1. Orthologous to human TSC1 (TSC complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Tsc1 基因产物(1)

mRNA Protein Name
NM_021854.2 NP_068626.1 hamartin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17355907 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adult locomotory behavior IMP
IMP: 通过突变表型推断
23435171 RGD
involved in cellular response to decreased oxygen levels IMP
IMP: 通过突变表型推断
23435171 RGD
involved in negative regulation of GTPase activity IMP
IMP: 通过突变表型推断
15611338 RGD
involved in negative regulation of TOR signaling IMP
IMP: 通过突变表型推断
23435171 RGD
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
17376623 RGD
involved in negative regulation of cellular response to oxidative stress IMP
IMP: 通过突变表型推断
23435171 RGD
involved in negative regulation of macroautophagy IMP
IMP: 通过突变表型推断
23435171 RGD
involved in negative regulation of neuron projection development IMP
IMP: 通过突变表型推断
17376623 RGD
involved in positive regulation of macroautophagy IDA
IDA: 通过直接分析推断
23435171 RGD
involved in positive regulation of stress fiber assembly IMP
IMP: 通过突变表型推断
15611338 RGD
involved in regulation of focal adhesion assembly IMP
IMP: 通过突变表型推断
15611338 RGD
involved in response to nutrient levels IEP
IEP: 通过表达模式推断
31787541 RGD
involved in response to peptide IEP
IEP: 通过表达模式推断
31787541 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell projection IDA
IDA: 通过直接分析推断
17376623 RGD
located in growth cone IDA
IDA: 通过直接分析推断
12226091 RGD
located in nucleus IDA
IDA: 通过直接分析推断
23435171 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
23435171 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

hamartin

tuberous sclerosis 1 protein homolog

相关产品

Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-134904 RMC-6272 Inhibitor 97.42% 否
HY-131976 BVDV-IN-1 Inhibitor 98.51% 否
HY-RS17222 Tsc1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-134922 NS1-IN-1 Inhibitor / 否
HY-RS02096 CCL26 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS15131 TSC1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-174756 Human CCL26 mRNA / 否
HY-RS23675 Tsc1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tsc1 NCBI NCBI:7248
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