2. Gene
  3. SPAG1 - sperm associated antigen 1 Gene

SPAG1 - sperm associated antigen 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：精子相关抗原 1

种属: Homo sapiens

同用名: SP75; TPIS; CT140; CILD28; DNAAF13; HSD-3.8; HEL-S-268

基因 ID: 6674 | 基因类型: protein coding

关于 SPAG1

Cytogenetic location: 8q22.2 Genomic coordinates (GRCh38): 8:100,158,038-100,241,904 (from NCBI)

This gene has 7 transcripts (splice variants), 273 orthologues, 18 paralogues and is associated with 3 phenotypes. Broad expression in colon (RPKM 8.4), testis (RPKM 7.5) and 22 other tissues.

功能概要

抗精子抗体与不明原因不孕症病例的相关性暗示了这些抗体在阻断受精方面的作用。改进免疫性不孕症的诊断和治疗，以及用于靶向避孕的蛋白质鉴定，都取决于相关精子抗原的鉴定和表征。该基因表达的蛋白质被不育妇女的抗精子凝集抗体识别。此外，用重组人蛋白免疫雌性大鼠会降低生育能力。该蛋白质定位于睾丸中生殖细胞的质膜和成熟精子的顶体后质膜。重组多肽结合 GTP 并表现出 GTPase 活性。因此，该蛋白可能调节参与精子发生和受精的 GTP 信号转导通路。该基因的两个转录变体编码相同的蛋白质。[RefSeq 提供，2008 年 7 月]

The correlation of anti-sperm Antibodies with cases of unexplained infertility implicates a role for these Antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating Antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein. [provided by RefSeq, Jul 2008]

SPAG1 基因产物(3)

mRNA Protein Name
NM_001374321.1 NP_001361250.1 sperm-associated antigen 1
NM_003114.5 NP_003105.2 sperm-associated antigen 1
NM_172218.3 NP_757367.1 sperm-associated antigen 1

SPAG1 蛋白结构

TPR_11

TPR_11: TPR repeat (212 - 273)

TPR_1

TPR_1: Tetratricopeptide repeat (276 - 309)

TPR_11

TPR_11: TPR repeat (445 - 518)

TPR_1

TPR_1: Tetratricopeptide repeat (524 - 551)

TPR_11

TPR_11: TPR repeat (624 - 687)

TPR_1

TPR_1: Tetratricopeptide repeat (691 - 723)

RPAP3_C

RPAP3_C: Potential Monad-binding region of RPAP3 (802 - 895)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 926 a.a.
蛋白主名 其他名称

sperm-associated antigen 1

TPR-containing protein involved in spermatogenesis

关联疾病

疾病名称 别名
Ciliary Dyskinesia, Primary, 28

Primary Ciliary Dyskinesia 28

CILD28

Primary Ciliary Dyskinesia 28 With Or Without Situs Inversus

Ciliary Dyskinesia, Primary, 28, With Or Without Situs Inversus

Ciliary Dyskinesia, Primary, 28, Without Situs Inversus

Dyskinesia, Ciliary, Primary, 28
Epilepsy, Nocturnal Frontal Lobe, 5

ENFL5

Autosomal Dominant Nocturnal Frontal Lobe Epilepsy 5

Epilepsy Nocturnal Frontal Lobe, 5

Nocturnal Frontal Lobe Epilepsy 5

Epilepsy, Frontal Lobe, Nocturnal, Type 5
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary
Infertility
Theileriasis

Theileriosis

Infection By Theileria
Kartagener Syndrome

Kartagener'S Syndrome
Situs Inversus

Situs Inversus Viscerum

Laterality Sequence

Complete Transposition

Siv
Visceral Heterotaxy

Situs Ambiguus

Heterotaxia

Heterotaxy Syndrome

Heterotaxy

Lateralization Defect

Situs Ambiguous

Left Isomerism

Htx

Ivemark Syndrome

Right Isomerism

Situs Ambiguus Viscerum

Incomplete Situs Inversus

Partial Situs Inversus

Heterotaxy, Visceral

Asplenia Syndrome

Bilateral Left-Sidedness

Polysplenia Syndrome

Moller Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13620 SPAG1 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SPAG1 MGD MGI:1349387
Felis catus SPAG1 VGNC VGNC:65595
Macaca mulatta SPAG1 VGNC VGNC:77849
Bos taurus SPAG1 VGNC VGNC:35164
Rattus norvegicus SPAG1 RGD RGD:1310702
Others SPAG1 NCBI
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