1. Gene
  2. HECTD3 - HECT domain E3 ubiquitin protein ligase 3 Gene

HECTD3 - HECT domain E3 ubiquitin protein ligase 3 Gene

中文名称:HECT 结构域 E3 泛素蛋白连接酶 3

种属: Homo sapiens

基因 ID: 79654 | 基因类型: protein coding

关于 HECTD3

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:45,002,548-45,011,324 (from NCBI)

This gene has 7 transcripts (splice variants) and 191 orthologues. Ubiquitous expression in duodenum (RPKM 25.9), small intestine (RPKM 22.6) and 25 other tissues.

功能概要

由该基因编码的蛋白质将泛素从 E2 泛素结合酶转移到目标底物,导致这些底物降解。已显示编码的蛋白质将泛素转移到 TRIOBP 以促进细胞周期进程,并转移到 STX8。[RefSeq 提供,2012 年 12 月]

The protein encoded by this gene transfers ubiquitin from an E2 ubiquitin-conjugating enzyme to targeted substrates, leading to the degradation of those substrates. The encoded protein has been shown to transfer ubiquitin to TRIOBP to facilitate cell cycle progression, and to STX8. [provided by RefSeq, Dec 2012]

HECTD3 基因产物(1)

mRNA Protein Name
NM_024602.6 NP_078878.3 E3 ubiquitin-protein ligase HECTD3
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18194665 GOA
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
18194665 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
18194665 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

HECTD3 蛋白结构

ANAPC10

ANAPC10: Anaphase-promoting complex, subunit 10 (APC10) (247 - 389)

HECT

HECT: HECT-domain (ubiquitin-transferase) (583 - 848)

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  • 861 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase HECTD3

HECT domain containing E3 ubiquitin protein ligase 3

直系同源

种属 基因名 来源 基因 ID
Bos taurus HECTD3 VGNC VGNC:29802
Mus musculus HECTD3 MGD MGI:1923858
Rattus norvegicus HECTD3 RGD RGD:1309823
Macaca mulatta HECTD3 VGNC VGNC:73240
Felis catus HECTD3 VGNC VGNC:62784