STARD5 - StAR related lipid transfer domain containing 5 Gene

中文名称：含 StAR 相关脂质转移结构域 5

种属: Homo sapiens

关于 STARD5

功能概要

含有类固醇生成急性调节相关脂质转移 (START) 结构域的蛋白质通常参与不同细胞内膜之间的脂质和胆固醇运输。该基因是编码 START 相关脂质转移蛋白的 StarD 亚家族的成员。该基因编码的蛋白质是一种胆固醇转运蛋白，还能够结合和转运其他与胆固醇/胆汁酸生物合成途径相关的甾醇衍生分子，例如 25-羟基胆固醇。其表达在内质网 (ER) 应激期间上调。该蛋白质被认为充当细胞溶质甾醇转运蛋白，可在细胞内膜之间移动胆固醇，例如从细胞质到 ER 以及从 ER 到高尔基体。该基因的可变剪接产生多个转录本变体。[RefSeq 提供，2016 年 1 月]

Proteins containing a steroidogenic acute regulatory-related lipid transfer (START) domain are often involved in the trafficking of lipids and Cholesterol between diverse intracellular membranes. This gene is a member of the StarD subfamily that encodes START-related lipid transfer proteins. The protein encoded by this gene is a Cholesterol transporter and is also able to bind and transport Other sterol-derived molecules related to the Cholesterol/bile acid biosynthetic pathways such as 25-hydroxycholesterol. Its expression is upregulated during endoplasmic reticulum (ER) stress. The protein is thought to act as a cytosolic sterol transporter that moves Cholesterol between intracellular membranes such as from the cytoplasm to the ER and from the ER to the Golgi apparatus. Alternative splicing of this gene produces multiple transcript variants. [provided by RefSeq, Jan 2016]