2. Gene
  3. ZRANB3 - zinc finger RANBP2-type containing 3 Gene

ZRANB3 - zinc finger RANBP2-type containing 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含锌指 RANBP2 型 3

种属: Homo sapiens

同用名: AH2; 4933425L19Rik

基因 ID: 84083 | 基因类型: protein coding

关于 ZRANB3

Cytogenetic location: 2q21.3 Genomic coordinates (GRCh38): 2:135,196,969-135,531,218 (from NCBI)

This gene has 11 transcripts (splice variants), 197 orthologues and 30 paralogues. Broad expression in testis (RPKM 1.8), thyroid (RPKM 0.8) and 24 other tissues.

功能概要

启用 ATP 依赖性 DNA/DNA 退火活性； K63 连接的多聚泛素修饰依赖性蛋白结合活性；和内切脱氧核糖核酸酶活性。参与多个过程，包括 DNA 代谢过程； DNA 倒带；和 DNA 重组的负调控。位于核复制叉和核质中。 [由基因组资源联盟提供，2022 年 4 月]

Enables ATP-dependent DNA/DNA annealing activity; K63-linked polyubiquitin modification-dependent protein binding activity; and endodeoxyribonuclease activity. Involved in several processes, including DNA metabolic process; DNA rewinding; and negative regulation of DNA recombination. Located in nuclear replication fork and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZRANB3 基因产物(3)

mRNA Protein Name
NM_001286568.2 NP_001273497.1 DNA annealing helicase and endonuclease ZRANB3 isoform 2
NM_001286569.1 NP_001273498.1 DNA annealing helicase and endonuclease ZRANB3 isoform 3
NM_032143.4 NP_115519.2 DNA annealing helicase and endonuclease ZRANB3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP-dependent DNA/DNA annealing activity IDA
IDA: 通过直接分析推断
21078962 GOA
enables DNA endonuclease activity IDA
IDA: 通过直接分析推断
22759634 GOA
NOT enables DNA helicase activity IDA
IDA: 通过直接分析推断
21078962 GOA
enables K63-linked polyubiquitin modification-dependent protein binding IDA
IDA: 通过直接分析推断
22704558 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22704558 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IDA
IDA: 通过直接分析推断
22704558 GOA
involved in DNA repair IDA
IDA: 通过直接分析推断
22759634 GOA
involved in DNA rewinding IDA
IDA: 通过直接分析推断
21078962 GOA
involved in negative regulation of DNA recombination IDA
IDA: 通过直接分析推断
22704558 GOA
involved in replication fork processing IDA
IDA: 通过直接分析推断
22704558 GOA
involved in replication fork reversal IDA
IDA: 通过直接分析推断
22704558 GOA
involved in response to UV IDA
IDA: 通过直接分析推断
22704558 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nuclear replication fork IDA
IDA: 通过直接分析推断
22704558 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZRANB3 蛋白结构

SNF2_N

SNF2_N: SNF2 family N-terminal domain (51 - 286)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (361 - 435)

zf-RanBP

zf-RanBP: Zn-finger in Ran binding protein and others (625 - 647)

HNH

HNH: HNH endonuclease (1011 - 1051)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1079 a.a.
蛋白主名 其他名称

DNA annealing helicase and endonuclease ZRANB3

annealing helicase 2

ZRANB3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ZRANB3 Q5FWF4 PCNA Homo sapiens P12004
Confocal
22759634
种属内
ZRANB3 Q5FWF4 PCNA Homo sapiens P12004
Anti Tag CoIP
22759634
种属内
ZRANB3 Q5FWF4 PCNA Homo sapiens P12004
Pull Down
22759634
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Schimke Immunoosseous Dysplasia

Schimke Immuno-Osseous Dysplasia

SIOD

Immunoosseous Dysplasia, Schimke Type

Schimke Syndrome

Immunoosseous Dysplasia Schimke Type

Spondyloepiphyseal Dysplasia - Nephrotic Syndrome

Spondyloepiphyseal Dysplasia Nephrotic Syndrome

Spondyloepiphyseal Dysplasia-Nephrotic Syndrome
Amelogenesis Imperfecta, Type If

Amelogenesis Imperfecta Type 1f

AI1F

Amelogenesis Imperfecta, Hypoplastic Type If

Amelogenesis Imperfecta Type If

Amelogenesis Imperfecta Hypoplastic Type If

Amelogenesis Imperfecta 1f
Chronic Inducible Urticaria
Hypotrichosis 7

Woolly Hair, Autosomal Recessive 2, With Or Without Hypotrichosis

HYPT7

Hypotrichosis, Localized, Autosomal Recessive 2

Lah2

Ah

Total Hypotrichosis, Mari Type

Wh/Ht

Hypotrichosis, Autosomal Recessive

Hypotrichosis, Total, Mari Type

Woolly Hair, Autosomal Recessive 2 With Or Without Hypotrichosis

Total Mari Type Hypotrichosis

Alopecia Universalis Congenita, Mari Type

Mari Type Alopecia Universalis Congenita

Autosomal Recessive Hypotrichosis

Autosomal Recessive Localized Hypotrichosis

Autosomal Recessive Woolly Hair With Or Without Hypotrichosis

Htl

Hypotrichoses

Hypotrichosis

Lah

Alopecia Universalis Congenita Mari Type

Hypotrichosis Autosomal Recessive

Hypotrichosis Localized Autosomal Recessive 2

Total Hypotrichosis Mari Type

Woolly Hair Autosomal Recessive 2

ARWH2

Woolly Hair Autosomal Recessive 2 With Or Without Hypotrichosis
Chronic Intestinal Vascular Insufficiency

Chronic Mesenteric Ischemia

Cmi - Chronic Mesenteric Ischaemia
Cerebellar Ataxia Type 9

Sca9
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16195 ZRANB3 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ZRANB3 MGD MGI:1918362
Macaca mulatta ZRANB3 VGNC VGNC:79486
Felis catus ZRANB3 VGNC VGNC:80416
Canis familiaris ZRANB3 VGNC VGNC:48849
Rattus norvegicus ZRANB3 RGD RGD:1564952
Bos taurus ZRANB3 VGNC VGNC:37373
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