2. Gene
  3. NOA1 - nitric oxide associated 1 Gene

NOA1 - nitric oxide associated 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：一氧化氮相关 1

种属: Homo sapiens

同用名: MTG3; hNOA1; C4orf14; hAtNOS1; mAtNOS1

基因 ID: 84273 | 基因类型: protein coding

关于 NOA1

Cytogenetic location: 4q12 Genomic coordinates (GRCh38): 4:56,963,350-56,977,606 (from NCBI)

This gene has 1 transcript (splice variant), 194 orthologues and 6 paralogues. Ubiquitous expression in colon (RPKM 10.1), duodenum (RPKM 8.9) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种核编码的 GTP 酶，在线粒体中起作用。翻译后，这种蛋白质被导入细胞核，然后进入核仁，然后被导出到线粒体。所编码的蛋白质是线粒体呼吸复合物的氧依赖性调节和线粒体蛋白质合成所必需的。[RefSeq 提供，2015 年 12 月]

The protein encoded by this gene is a nuclear-encoded GTPase that functions in the mitochondrion. Upon translation, this protein is imported into the nucleus and then into the nucleolus before being exported to the mitochondrion. The encoded protein is required for oxygen-dependent regulation of mitochondrial respiratory complexes and for mitochondrial protein synthesis. [provided by RefSeq, Dec 2015]

NOA1 基因产物(1)

mRNA Protein Name
NM_032313.4 NP_115689.1 nitric oxide-associated protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTP binding IDA
IDA: 通过直接分析推断
19103604 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19103604 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mitochondrion organization IMP
IMP: 通过突变表型推断
19103604 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with matrix side of mitochondrial inner membrane IDA
IDA: 通过直接分析推断
19103604 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NOA1 蛋白结构

MMR_HSR1

MMR_HSR1: 50S ribosome-binding GTPase (340 - 501)

  • 0
  • 200
  • 400
  • 600
  • 698 a.a.
蛋白主名 其他名称

nitric oxide-associated protein 1

mitochondrial GTPase 3 homolog

NOA1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NOA1 Q8NC60 NDUFA9 Homo sapiens Q16795
Pull Down
19103604
种属内
NOA1 Q8NC60 NDUFA9 Homo sapiens Q16795
Anti Bait CoIP
19103604
种属内
NOA1 Q8NC60 DAP3 Homo sapiens P51398
Anti Bait CoIP
19103604
种属内
NOA1 Q8NC60 DAP3 Homo sapiens P51398
Pull Down
19103604
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Sarcomatosis
Spinocerebellar Ataxia 28

Spinocerebellar Ataxia Type 28

SCA28

Ataxia, Spinocerebellar, Type 28
Cerebrooculofacioskeletal Syndrome 1

Cofs Syndrome

COFS1

Pena-Shokeir Syndrome Type 2

Cofs

Pena-Shokeir Syndrome, Type Ii

Cerebrooculofacioskeletal Syndrome

Cerebro-Oculo-Facio-Skeletal Syndrome 1

Pena Shokeir Syndrome Type 2
Cardiomyopathy, Dilated, 1e

Left Ventricular Noncompaction 9

Left Ventricular Noncompaction 5

Dilated Cardiomyopathy 1e

Dilated Cardiomyopathy 1s

CMD1E

Cdcd2

Cardiomyopathy, Dilated, 1y

CMD1Y

Cardiomyopathy, Dilated, 1s

CMD1S

Dilated Cardiomyopathy 1y

Dilated Cardiomyopathy With Conduction Defect 2

Dilated Cardiomyopathy With Conduction Disorder And Arrhythmia

Cardiomyopathy, Dilated, With Conduction Disorder And Arrhythmia

Cardiomyopathy, Dilated, With Conduction Defect 2

Cardiomyopathy Dilated With Conduction Defect Type 2

Cardiomyopathy, Dilated 1e

Cardiomyopathy, Dilated 1s

Cardiomyopathy, Dilated 1y

Left Ventricular Non-Compaction 5

LVNC5

Left Ventricular Non-Compaction 9

LVNC9

Cardiomyopathy, Dilated, Type 1e

Cardiomyopathy, Dilated, Type 1s

Cardiomyopathy, Dilated, Type 1y
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09397 NOA1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22262 Noa1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28784 Noa1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus NOA1 VGNC VGNC:63843
Bos taurus NOA1 VGNC VGNC:56755
Macaca mulatta NOA1 VGNC VGNC:75269
Mus musculus NOA1 MGD MGI:1914306
Rattus norvegicus NOA1 RGD RGD:1359460
Canis familiaris NOA1 VGNC VGNC:43871
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