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  3. Lixumistat hydrochloride

Lixumistat hydrochloride  (Synonyms: HL271; IM156 hydrochloride; HL156A hydrochloride)

目录号: HY-136093
产品使用指南

Lixumistat (HL271) hydrochloride 是二甲双胍 (HY-B0627) 的化学衍生物,是一种强效的 AMPK 激活剂,能增加 AMPK 的磷酸化水平。Lixumistat hydrochloride 在动物模型中可缓解与年龄相关的认知障碍。Lixumistat hydrochloride 是一种有效的氧化磷酸化 (OXPHOS) 抑制剂,可用于实体肿瘤的研究。

在相同的摩尔浓度下,化合物盐形式与游离形式有相同的生物活性,但盐形式 Lixumistat acetate 通常具有更好的水溶性和稳定性。

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Lixumistat hydrochloride Chemical Structure

Lixumistat hydrochloride Chemical Structure

CAS No. : 1422365-52-3

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Lixumistat hydrochloride 的其他形式现货产品:

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lixumistat (HL271) hydrochloride (IM156 hydrochloride; HL156A hydrochloride), a chemical derivative of Metformin (HY-B0627), is a potent AMPK activator that increases AMPK phosphorylation. Lixumistat hydrochloride attenuates aging-associated cognitive impairment in animal model[1][2]. Lixumistat hydrochloride is a potent oxidative phosphorylation (OXPHOS) inhibitor which can be used for the research of solid tumors[3].

IC50 & Target

AMPK[1][2], OXPHOS[3]

体外研究
(In Vitro)

Lixumistat hydrochloride (0.31-10 μM) phosphorylates AMPKα1 Thr172 in a dose- and time-dependent manner in NIH3T3 mouse fibroblast cells[1].
Lixumistat hydrochloride does not affect the expression of key factors involved in glucose homeostasis such as glucose-6-phosphatase (G6pase) or phosphoenolpyruvate carboxykinase 1 (Pck1)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: NIH3T3 cells
Concentration: 0.31 μM, 0.62 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM
Incubation Time: 4 hours
Result: Significantly increased the AMPK phosphorylation rate.
体内研究
(In Vivo)

Lixumistat (hydrochloride) does not affect metabolic regulation assessed by body weight, blood glucose, insulin levels and lipid metabolite content in mice with diet-induced obesity[1].
Lixumistat (hydrochloride) (50 mg/kg; for 2 months) does not affect body weight, general locomotion, or anxiety[2].
Lixumistat (hydrochloride) significantly attenuates the aging-induced decline in novel object recognition memory and spatial working memory[2].
Lixumistat (hydrochloride) significantly increases AMPK activation in the hippocampus of aged mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice (young group/12-16 weeks, old groups/20-22 months)[2]
Dosage: 50 mg/kg
Administration: Oral administration (in drinking water), for 2 months
Result: Attenuated age-related cognitive decline.
Clinical Trial
分子量

351.76

Formula

C13H17ClF3N5O

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Lixumistat hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Lixumistat hydrochloride
目录号:
HY-136093
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