2. Metabolic Enzyme/Protease Immunology/Inflammation MAPK/ERK Pathway Stem Cell/Wnt NF-κB
  3. MMP COX Interleukin Related p38 MAPK ERK Keap1-Nrf2
  4. Hydrangenol

Hydrangenol 是一种口服有效的抗光老化化合物。可从绣球花 (Hydrangea serrata) 的叶中分离。Hydrangenol 通过降低 MMP 和炎症细胞因子的表达，增加保湿因子和抗氧化基因的水平来预防皱纹的形成。

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Hydrangenol Chemical Structure

Hydrangenol Chemical Structure

CAS No. : 480-47-7

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Hydrangenol 相关抗体

Top Publications Citing Use of Products

查看 MMP 亚型特异性产品:

查看所有亚型
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

查看 COX 亚型特异性产品:

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COX COX-1 COX-2 COX-3

查看 p38 MAPK 亚型特异性产品:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

查看 ERK 亚型特异性产品:

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ERK ERK1 ERK2 ERK5 ERK8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Hydrangenol is an orally active antiphotoaging compound. It can be isolated from Hydrangea serrata leaves. Hydrangenol prevents wrinkle formation by reducing MMP and inflammatory cytokine expression and increasing moisturizing factors and antioxidant genes level[1].

IC50 & Target[1]

MMP-1

 

MMP-3

 

COX-2

 

IL-6

 

体内研究
(In Vivo)

Hydrangenol (5, 10, 20, 或 40 mg/kg; 口服; 每日给药，共 7 周) 减轻 uvb 照射 HR-1 无毛小鼠的皱纹形成、背厚、脱水和胶原蛋白降解[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: UVB-irradiated HR-1 hairless mice[1]
Dosage: 5, 10, 20, or 40 mg/kg
Administration: Oral gavage; daily for 7 weeks
Result: Increased the expression of involucrin, filaggrin, and aquaporin-3 (AQP3) as well as hyaluronic acid (HA) production via hyaluronidase (HYAL)-1/-2 downregulation.
Increased the expression of Pro-COL1A1.
Decreased the expression matrix metalloproteinase (MMP)-1/-3, cyclooxygenase-2 (COX-2), and interleukin-6 (IL-6).
Attenuated the phosphorylation of mitogen-activated protein kinases (MAPKs) including ERK and p38, activator protein 1 (AP-1) subunit, and signal transduction and activation of transcription 1 (STAT1).
Upregulated the expression of nuclear factor-E2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), NAD(P)H quinone dehydrogenase 1 (NQO-1), glutamate cysteine ligase modifier subunit (GCLM), and glutamate cysteine ligase catalysis subunit (GCLC).
分子量

256.25

Formula

C15H12O4
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Hydrangenol 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hydrangenol480-47-7MMPCOXInterleukin Relatedp38 MAPKERKKeap1-Nrf2Matrix metalloproteinasesCyclooxygenaseILExtracellular signal regulated kinasesInhibitorinhibitorinhibit

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