(-)-Hydroxycitric acid  (Synonyms: (-)-羟基柠檬酸; Garcinia acid)

(-)-Hydroxycitric acid (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. (-)-Hydroxycitric acid is a potent and competitive and orally active inhibitor of ATP citrate lyase. (-)-Hydroxycitric acid suppresses the fatty acid synthesis, lipogenesis, food intake, and induced weight loss^[1][2].

(-)-Hydroxycitric acid (0-50 µM) 可减少原代鸡肝细胞中的脂滴积累，并降低 ATP-柠檬酸裂解酶、脂肪酸合酶和甾醇调节元件结合蛋白-1c mRNA 水平^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(-)-Hydroxycitric acid (1.0 mg/kg 每胚胎，注射) 可降低鸡胚胎中的脂滴积累、甘油三酯含量、脂肪生成因子 mRNA 水平并增加脂肪分解因子 mRNA 表达^[3]。
(-)-Hydroxycitric acid (口服一次) 在禁食的雄性和雌性白化大鼠中显示 LD50 大于 5000 mg/kg^[5]。
(-)-Hydroxycitric acid (1000-3000 mg/kg 饮食，连续 8 周) 可降低大鼠体重增加、提高饲料转化率并促进蛋白质合成^[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

208.12

C₆H₈O₈

27750-10-3

固体

White to off-white

(-)-羟基柠檬酸

Room temperature in continental US; may vary elsewhere.

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

• [1]. B. S. Jena, et al. Chemistry and Biochemistry of (−)-Hydroxycitric Acid from Garcinia. J. Agric. Food Chem. 2002, 50, 1, 10-22.

  [2]. Hayamizu K, et al. Effects of garcinia cambogia (Hydroxycitric Acid) on visceral fat accumulation: a double-blind, randomized, placebo-controlled trial. Curr Ther Res Clin Exp. 2003 Sep;64(8):551-67.  [Content Brief]

  [3]. Li S, et al. (-)-Hydroxycitric Acid Influenced Fat Metabolism via Modulating of Glucose-6-phosphate Isomerase Expression in Chicken Embryos. J Agric Food Chem. 2019 Jul 3;67(26):7336-7347.  [Content Brief]

  [4]. Li L, et al. (-)-Hydroxycitric Acid Reduced Lipid Droplets Accumulation Via Decreasing Acetyl-Coa Supply and Accelerating Energy Metabolism in Cultured Primary Chicken Hepatocytes. Cell Physiol Biochem. 2017;43(2):812-831.  [Content Brief]

  [5]. Ohia SE, et al. Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX). Mol Cell Biochem. 2002 Sep;238(1-2):89-103.  [Content Brief]

  [6]. Han N, et al. (-)-Hydroxycitric Acid Nourishes Protein Synthesis via Altering Metabolic Directions of Amino Acids in Male Rats. Phytother Res. 2016 Aug;30(8):1316-29.  [Content Brief]