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  3. Hygrolidin

Hygrolidin 

目录号: HY-133537
产品使用指南

Hygrolidin 是一种 16 元大环内酯类抗生素,来自于吸水链霉菌 (Streptomyces hygroscopicus) D-1166。Hygrolidin 对 Valsa ceratosperma 具有抗真菌活性。Hygrolidin 诱导 p21 表达并中止 G1 和 S 期的细胞周期进程。Hygrolidin 具有抗肿瘤活性。

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Hygrolidin Chemical Structure

Hygrolidin Chemical Structure

CAS No. : 83329-73-1

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Description

Hygrolidin is a 16-membered macrolide antibiotic produced by Streptomyces hygroscopicus D-1166. Hygrolidin has anti-fungus activity against Valsa ceratosperma. Hygrolidin induces p21 expression and abrogates cell cycle progression at G1 and S phases. Hygrolidin has antitumor activity[1][2][3].

In Vitro

Hygrolidin (0.1, 1 μg/ml; for 24 h) increases both G1 and S phase populations and decreases M phase population[1].
Hygrolidin (0.1, 1, 10 μg/ml; for 24 h) decreases the amounts of cdk4, cyclin D, cyclin B and increases the amounts of cyclin E and p21. Hygrolidin-induced p21 preferentially associates with cyclin A-cdk2 complex and inhibits it[1].
Hygrolidin (0.1, 1 μg/ml; for 24 h) selectively induces p21 in DLD-1 cells at mRNA level, but not in WI-38 fibroblasts[1].
Hygrolidin, for 3 days, inhibits growth of various cell lines including DLD-1 colon cancer, LNCaP prostate cancer, K562 leukemia cells, LNCaP prostate cancer, EL-4 lymphoma (IC50s = 1.0-33 ng/ml, respectively)[1].
Hygrolidin shows growth inhibition on Trypanosoma cruzi (IC50=1.1 nM), Trypanosoma brucei brucei (IC50=77 nM), and Leishmania donovani (IC50=72.5 nM)[3].

Cell Cycle Analysis[1]

Cell Line: DLD-1 cells
Concentration: 0.1, 1 μg/ml
Incubation Time: For 24 hours
Result: Increased both G1 and S phase populations and decreased M phase population.

Western Blot Analysis[1]

Cell Line: DLD-1 cells
Concentration: 0.1, 1, 10 μg/ml
Incubation Time: For 24 hours
Result: Decreased the amounts of cdk4, cyclin D, cyclin B and increased the amounts of cyclin E and p21.

RT-PCR[1]

Cell Line: DLD-1 or WI-38 cells
Concentration: 0.1, 1 μg/ml
Incubation Time: For 24 hours
Result: Selectively induced p21 in DLD-1 cells at mRNA level, but not in WI-38 fibroblasts.
Molecular Weight

690.86

Formula

C₃₈H₅₈O₁₁

CAS No.

83329-73-1

SMILES

O=C(O[C@@H]1C[C@@]([C@@H](C)[C@H](O)[C@@H]([C@H]([C@@H](OC)/C=C/C=C(C)/C[C@H](C)[C@H](O)[C@H](C)/C=C(C)/C=C2\C)OC2=O)C)(O)O[C@H](CC)[C@@H]1C)/C=C/C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

HygrolidinAntibioticFungalADC Cytotoxin16-memberedmacrolidep21cycleG1Sphasescdk4cyclin Dcyclin Bcyclin EDLD-1LNCaPK562Inhibitorinhibitorinhibit

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Hygrolidin
目录号:
HY-133537
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