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IN04 是富含亮氨酸重复激酶 1 (LRRK1) 的抑制剂。IN04 可完全阻断 ATP 与人 LRRK1 激酶域的结合,从而抑制 LRRK1 的激酶活性。IN04 可显著削弱破骨细胞的骨吸收能力,IC50 值为 5.72 μM。IN04 可用于骨质疏松症研究。

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IN04

IN04 Chemical Structure

CAS No. : 838816-57-2

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IN04 is a inhibitor of leucine-rich repeat kinase 1 (LRRK1). IN04 can completely block the binding of ATP to the human LRRK1 kinase domain, thereby inhibiting the kinase activity of LRRK1. IN04 can significantly impair the bone resorption ability of osteoclasts, with an IC50 value of 5.72 μM. IN04 can be used for the study of osteoporosis[1][2].

分子量

429.45

Formula

C20H19N3O6S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

IN04 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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IN04
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HY-W107722
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