2. Metabolic Enzyme/Protease Apoptosis Immunology/Inflammation NF-κB
  3. Endogenous Metabolite Ferroptosis Reactive Oxygen Species (ROS) Keap1-Nrf2 Apoptosis
  4. L-Cystine disodium monohydrate

L-Cystine disodium monohydrate 是具有口服活性的 L-Cysteine (HY-Y0337) 的细胞外形式，存在于植物和动物的蛋白质中。L-Cystine disodium monohydrate 升高 Nrf2 蛋白表达含量并激活 Nrf2 转录因子。L-Cystine disodium monohydrate 减少了 ROS 的产生，并保护细胞免受氧化剂或 Doxorubicin (HY-15142A) 诱导的凋亡 (apoptosis)。L-Cystine disodium monohydrate 与 L-theanine (HY-15121) 联合使用通过提高谷胱甘肽 (GSH) 水平和 T 辅助细胞 2 (Th2) 介导的反应，增强了抗原特异性 IgG 的产生。L-Cystine disodium monohydrate 有望用于囊性尿症和肾结石的研究。

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L-Cystine disodium monohydrate

L-Cystine disodium monohydrate Chemical Structure

CAS No. : 199329-53-8

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L-Cystine disodium monohydrate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

L-Cystine disodium monohydrate is an orally active extracellular form of L-Cysteine (HY-Y0337), occurring in proteins of plants and animals. L-Cystine disodium monohydrate elevates Nrf2 protein expression and activates Nrf2 transcription factor. L-Cystine disodium monohydrate reduces ROS generation and protects against oxidant- or Doxorubicin (HY-15142A)-induced apoptosis. L-Cystine disodium monohydrate combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine disodium monohydrate is promising for research of cystinuria and kidney stones[1][2][3][4][5][6].

体外研究
(In Vitro)

L-Cystine (83 µM 或 200 µM, 24 或 72 小时) disodium monohydrate 可有效逆转 Sulfasalazine (HY-14655) 和 Erastin (HY-15763) 在 Huh6 细胞中的生长抑制作用[1]。
L-Cystine ( 0.8 mM, 4 小时) disodium monohydrate 在 HeLa 细胞中以 Keap1 依赖的方式诱导 Nrf2 蛋白表达含量升高[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

L-Cystine disodium monohydrate 相关抗体:

Cell Viability Assay[1]

Cell Line: Huh6 and Huh7 cells
Concentration: 83 µM or 200 µM
Incubation Time: 72 h or 24 h
Result: The degree of growth inhibition by Sulfasalazine (HY-14655) or Erastin (HY-15763) was greater in medium containing a physiological level of 83 μM L-cystine than in medium containing 200 μM L-cystine in Huh6 and Huh7 cells.

Western Blot Analysis[6]

Cell Line: HeLa cells
Concentration: 0.2 mM, 0.8 mM
Incubation Time: 4 h
Result: Was sufficient for producing Nrf2 protein elevation at 0.2 mM in HeLa cells.
Induced Nrf2 in a Keap1-dependent manner in HeLa cells.
体内研究
(In Vivo)

L-Cystine (280 mg/kg, 口服, 11 天) disodium monohydrate 与 L-theanine (HY-15121) 一起给药，部分通过提高小鼠谷胱甘肽 (GSH) 水平和 T helper 2 (Th2) 介导的应答来增强抗原特异性 IgG 的产生[2]。
L-Cystine (200 mg/kg, 口服, 11 天) disodium monohydrate 与 L-theanine (HY-15121) (80 mg/kg, 口服, 11 天) 在 DNP-KLH 抗原刺激后 6 小时显著降低小鼠血清 IL-10/IFN-γ 比值，但在 DNP-KLH 抗原刺激后 24 小时升高血清 IL-10/IFN-γ 比值[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nine-week-old female BALB/c mice[2]
Dosage: 140, 280 and 560 mg/kg
Administration: p.o. administration for 11 days
Result: Significantly increased IgG and IgM antibody production administrated with L-theanine (HY-15121) after DNP-dextran and DNP-KLH antigenic stimulation in mice.
分子量

302.28

Formula

C6H12N2Na2O5S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

L-Cystine disodium monohydrate 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Cystine disodium199329-53-8Endogenous MetaboliteFerroptosisReactive Oxygen Species (ROS)Keap1-Nrf2ApoptosisInhibitorinhibitorinhibit

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