2. Metabolic Enzyme/Protease Anti-infection GPCR/G Protein
  3. Bacterial Endogenous Metabolite Hydroxycarboxylic Acid Receptor (HCAR)
  4. Lactic acid sodium (60% w/w in water)

Lactic acid sodium (60% w/w in water)  (Synonyms: DL-Lactic acid sodium; E-270 sodium)

目录号: HY-B2227B 纯度: 98.0%
COA 产品使用指南 技术支持

Lactic acid (DL-Lactic acid) sodium (60% w/w in water) 是一种羟基羧酸受体 1 (HCAR1) 激活剂和诱导赖氨酸残基乳酰化的表观遗传调节剂。Lactic acid sodium (60% w/w in water) 是糖酵解终产物，弥补了糖酵解和氧化磷酸化之间的差距。Lactic acid sodium (60% w/w in water) 是一种肿瘤代谢物，在抗肿瘤免疫中具有乳酸的免疫保护作用。Lactic acid sodium (60% w/w in water) 还具有抗菌活性，可用作食品保鲜剂。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CAS No. : 72-17-3

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
200 μL ￥210
In-stock
1 mL ￥350
In-stock
2 mL ￥560
In-stock
5 mL ￥896
In-stock
10 mL ￥1169
In-stock
50 mL   询价  
100 mL   询价  

* Please select Quantity before adding items.

Lactic acid sodium (60% w/w in water) 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 37 篇科研文献

IP
WB
IF
RT-PCR

    Lactic acid sodium (60% w/w in water) purchased from MCE. Usage Cited in: Redox Biol. 2025 Apr:81:103553.  [Abstract]

    Immunoblot and quantification analyses of NFS1 in HCC cells incubated with 0, 5, or 10 mM lactate after being subjected to either a 47 °C or 37 °C water bath.

    Lactic acid sodium (60% w/w in water) purchased from MCE. Usage Cited in: Cell Death Dis. 2025 Feb 28;16(1):144.  [Abstract]

    Co-IP detected the effect of lactate on YY1 protein lactylation modification.

    Lactic acid sodium (60% w/w in water) purchased from MCE. Usage Cited in: Cell Death Dis. 2025 Feb 28;16(1):144.  [Abstract]

    Lactate (25 mM) significantly increases the mRNA and protein expression of FBXO33.

    Lactic acid sodium (60% w/w in water) purchased from MCE. Usage Cited in: Cell Death Dis. 2025 Mar 20;16(1):193.  [Abstract]

    Lactate sodium (5-15 mM; 24 h) ​​results​​ in increased H4K12la (red) levels in CCSCs compared to the control group.

    Lactic acid sodium (60% w/w in water) purchased from MCE. Usage Cited in: J Exp Clin Cancer Res. 2024 Mar 5;43(1):68.  [Abstract]

    Lactate sodium increases IGF-1R levels in PI-resistant KAS-6/1 and U266 cells.

    Lactic acid sodium (60% w/w in water) purchased from MCE. Usage Cited in: Cell Res. 2023 Sep;33(9):679-698.  [Abstract]

    Lactate (NALA) (300 mM; 24 h) significantly upregulates α-MHC K1897 lactylation in H9c2 cells.

    Lactic acid sodium (60% w/w in water) purchased from MCE. Usage Cited in: J Ginseng Res. 2024 May;48(3):298-309.

    The expression level of METTL3, YTHDF1, YTHDF2, and YTHDC1 in NB4-R1 and NB4-R2 cells treated with 20 μM oxamate or 20 μM lactate or 1 μM ATRA for 48 h was detected via qRT-PCR.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium (60% w/w in water) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium (60% w/w in water) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity[1][2]. Lactic acid sodium (60% w/w in water) also has antimicrobial activity, which can be used as a food preservative[3].

    体外研究
    (In Vitro)

    Lactic acid (20 mM；24、48 小时) sodium (60% w/w in water) 导致细胞增殖和迁移显着减少，作用并将细胞代谢转变为氧化磷酸化[1]。
    Lactic acid (20 mM；24 小时) sodium (60% w/w in water) 显示 MCT1 和 HCAR1 的蛋白质和 mRNA 表达水平增加[1]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Lactic acid sodium (60% w/w in water) 相关抗体:

    Cell Proliferation Assay[1]

    Cell Line: Uveal melanoma 92.1 cells
    Concentration: 20 mM
    Incubation Time: 24, 48 h
    Result: Inhibited cell proliferation and migration.

    Western Blot Analysis[1]

    Cell Line: Uveal melanoma 92.1 cells
    Concentration: 20 mM
    Incubation Time: 24 h
    Result: Showed an increase in the protein expression levels of MCT1 and HCAR1

    RT-PCR[1]

    Cell Line: Uveal melanoma 92.1 cells
    Concentration: 20 mM
    Incubation Time: 24 h
    Result: Induced a significant increase in mRNA expression levels of SLC16A1 and HCAR1.
    体内研究
    (In Vivo)

    Lactic acid (1.6 g/kg；pH 7.4；皮下注射；每天一次；第 8 天至 30 天) sodium (60% w/w in water) 在 MC38 结肠癌模型中显示出 CD8+ T 细胞依赖性肿瘤生长抑制作用[2]。
    Note: 动物体内给药前需要将工作液 PH 调至 7.4 左右。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Female C57BL/6 mice with MC38 colon cancer cells[2]
    Dosage: 1.6 g/kg
    Administration: Subcutaneous; daily from Day 8 to 30 days
    Result: Significantly suppressed tumor growth.
    Clinical Trial
    分子量

    112.06

    Formula

    C3H5NaO3
    CAS 号
    性状

    液体（密度：1.33 g/cm3）

    颜色

    Colorless to light yellow

    中文名称

    乳酸钠
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Solution, -20°C, 2 years
    溶解性数据
    细胞实验： 

    H2O 中的溶解度 : ≥ 150 mg/mL (1338.57 mM)

    * "≥" means soluble, but saturation unknown.

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
    您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
    纯度 & 产品资料

    纯度: ≥98.0%

    COA (287 KB)

    产品使用指南 (1538 KB)
    参考文献

    Lactic acid sodium (60% w/w in water) 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 8.9238 mL 44.6190 mL 89.2379 mL 223.0948 mL
    5 mM 1.7848 mL 8.9238 mL 17.8476 mL 44.6190 mL
    10 mM 0.8924 mL 4.4619 mL 8.9238 mL 22.3095 mL
    15 mM 0.5949 mL 2.9746 mL 5.9492 mL 14.8730 mL
    20 mM 0.4462 mL 2.2309 mL 4.4619 mL 11.1547 mL
    25 mM 0.3570 mL 1.7848 mL 3.5695 mL 8.9238 mL
    30 mM 0.2975 mL 1.4873 mL 2.9746 mL 7.4365 mL
    40 mM 0.2231 mL 1.1155 mL 2.2309 mL 5.5774 mL
    50 mM 0.1785 mL 0.8924 mL 1.7848 mL 4.4619 mL
    60 mM 0.1487 mL 0.7436 mL 1.4873 mL 3.7182 mL
    80 mM 0.1115 mL 0.5577 mL 1.1155 mL 2.7887 mL
    100 mM 0.0892 mL 0.4462 mL 0.8924 mL 2.2309 mL

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Lactic acid sodium (60% w/w in water)72-17-3DL-Lactic acidE-270乳酸钠E270E 270BacterialEndogenous MetaboliteHydroxycarboxylic Acid Receptor (HCAR)hydroxycarboxylic acid receptor 1HCAR1epigeneticlysine residues lactylationglycolysisoxidative phosphorylationoncometaboliteanti-tumorInhibitorinhibitorinhibit

    您最近查看的产品:

    Your information is safe with us. * Required Fields.

       产品名称：

    		  

    * 需求量：

    * 客户姓名：

    		 

    * Email：

    * 电话：

    		 

    * 公司或机构名称：

       留言给我们：

    Bulk Inquiry

    Inquiry Information

    产品名称：
    Lactic acid sodium (60% w/w in water)
    目录号：
    HY-B2227B
    需求量：

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

       产品名称：

    		  

    * Lot #：

    * 客户姓名：

    		 

    * Email：

       电话：

    		 

    * 部门：

    * 公司或机构名称：

    		 

       留言给我们：

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.

    嗨！很高兴为您提供帮助！

    尊敬的 MCE 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z