1. Apoptosis
  2. Survivin
  3. LLP-3

LLP-3 是一种有效的 Survivin 抑制剂,可扰乱癌细胞中的 Survivin-Ran 蛋白复合物作用。LLP-3 可用于多形性胶质母细胞瘤(GBM) 的研究。

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LLP-3 Chemical Structure

LLP-3 Chemical Structure

CAS No. : 1453835-43-2

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1 mg ¥1836
3 - 4 周
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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LLP-3 is a potent Survivin inhibitor that disrupts the Survivin-Ran interaction in cancer cells. LLP-3 can be used in the research of Glioblastoma multiforme (GBM)[1].

IC50 & Target

Survivin[1]

体外研究
(In Vitro)

LLP-3 (20 μM, 24 h) impaires the binding of Survivin to Smac/DIABLO (proapoptotic protein), without affecting the interaction of Survivin with other chromosomal passenger complex (CPC) proteins[1].
LLP-3 (20 μM, 24 h) decreases the Survivin-Ran interaction in U87 cells[1].
LLP-3 (20 μM, 24 h) arrests cell in G0-G1 phase and subsequent tumor cell death[1].
LLP-3 (20 μM, 24 h) triggers caspase-dependent apoptosis in HT1080 cells[1].
LLP-3 (0-100 μM, 72 h) inhibits tumor cells survival by p53-mediated inhibition[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: U87E6, U87MG cell
Concentration: 0-100 μM
Incubation Time: 72 h
Result: Inhibited tumor cells survival with IC50 values of 13.6 μM (U87E6) and 38.1 μM (U87MG).

Cell Cycle Analysis[1]

Cell Line: U87 cells
Concentration: 20 μM
Incubation Time: 24 h
Result: Reduced the proportions of cells in the S and G2-M phases (from 9% to 5%, and from 25% to 17%, respectively).
Increased G0-G1 cell population (from 60% to 74%).

Immunofluorescence[1]

Cell Line: U87, HT1080 cells
Concentration: 40 μM
Incubation Time: 24 h
Result: Weakened the colocalization of TPX2 with the acetylated α-tubulin.
体内研究
(In Vivo)

LLP-3 (intraperitoneal injection, 25 mg/kg, for 10 days) prolongs survival of GBM sphere-derived tumor mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: GBM sphere-derived tumor models (GBM83 and 1600)[1]
Dosage: 25 mg/kg
Administration: Intraperitoneal injection, for 10 days (days 10–14 and days 17–21)
Result: Prolonged the survival of tumor-burden mice without exhibiting any lethality of mice until day 35.
分子量

534.99

Formula

C32H23ClN2O4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

LLP-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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