2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. LY3526318

LY3526318 是一种口服有效、选择性 TRPA1 拮抗剂 (IC50=5-6μM)。LY3526318 阻断 TRPA1 通道，抑制由该通道介导的疼痛信号转导，发挥镇痛活性。LY3526318 主要用于慢性疼痛相关领域的研究，如糖尿病周围神经性疼痛、慢性下腰痛以及骨关节炎引发的疼痛等的研究。

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LY3526318

LY3526318 Chemical Structure

CAS No. : 1889218-34-1

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规格 价格 是否有货 数量
5 mg ￥5920
7 - 9 周
10 mg 询价 7 - 9 周
25 mg 询价 7 - 9 周
50 mg 询价 7 - 9 周
100 mg   询价  
200 mg   询价  

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Customer Review

LY3526318 相关抗体

Top Publications Citing Use of Products

查看 TRP Channel 亚型特异性产品:

查看所有亚型
TRPC TRPM TRPV TRPA TRPML

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LY3526318 is an orally active, selective TRPA1 antagonist (IC50=5-6μM). LY3526318 blocks TRPA1 channels, inhibits pain signal transduction mediated by the channel, and exerts analgesic activity. LY3526318 is mainly used in the research of chronic pain-related fields, such as diabetic peripheral neuropathy, chronic low back pain, and pain caused by osteoarthritis[1][2].

IC50 & Target

TRPA1

 

体外研究
(In Vitro)

LY3526318 可阻断 Allyl Isothiocyanate (HY-B1515) 激活的瞬时 TRPA1 内向电流的效力，对人类、大鼠、狗和食蟹猴的 TRPA1 离子通道的 IC50 分别为 13.5 nM，55.7 nM，7.6 nM，8.2 nM[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LY3526318 相关抗体:
分子量

556.46

Formula

C23H19F3N10O4
CAS 号
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

LY3526318 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY35263181889218-34-1LY 3526318LY-3526318TRP ChannelTransient receptor potential channelsInhibitorinhibitorinhibit

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产品名称：
LY3526318
目录号：
HY-171846
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