1. Apoptosis
  2. Bcl-2 Family
  3. Mcl1-IN-8

Mcl1-IN-8 

目录号: HY-122627
产品使用指南

Mcl1-IN-8 (Comp8) 是 Mcl-1-PUMA 的抑制剂,Ki 值为0.3 μM。Mcl1-IN-8 (Comp8) 在下调PUMA依赖的凋亡的同时还能抑制Mcl-1介导的癌细胞抗凋亡作用。

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Mcl1-IN-8 Chemical Structure

Mcl1-IN-8 Chemical Structure

CAS No. : 678158-55-9

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Description

Mcl1-IN-8 (Comp8) is a Mcl-1-PUMA interface inhibitor, with a Ki of 0.3 μM. Mcl1-IN-8 (Comp8) exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells[1].

IC50 & Target[1]

Mcl-1

0.3 μM (Ki)

Molecular Weight

393.50

Formula

C₂₂H₂₃N₃O₂S

CAS No.

678158-55-9

SMILES

O=C1N=C(N2CCN(CCO)CC2)S/C1=C\C3=CC=C(C4=CC=CC=C4)C=C3

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
Mcl1-IN-8
目录号:
HY-122627
需求量:

Mcl1-IN-8

Cat. No.: HY-122627