2. Peptides
  3. MOG peptide (35-55)

MOG peptide (35-55) 

目录号: HY-P3719 纯度: 98.72%
COA 产品使用指南

摩尔计算器

MOG peptide (35-55) 是髓鞘少突胶质细胞糖蛋白 (MOG) 免疫原肽的 35-55 片段。MOG peptide (35-55) 特异性作用于 CD4+ T 细胞，能够诱导实验性自身免疫性脑脊髓炎 (EAE) 动物模型。

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MOG peptide (35-55) Chemical Structure

MOG peptide (35-55) Chemical Structure

CAS No. : 2022956-48-3

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1 mg ￥500
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5 mg ￥1250
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10 mg ￥2000
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Customer Review

MOG peptide (35-55) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MOG peptide (35-55) is a fragment 35-55 of myelin oligodendrocyte glycoprotein (MOG) immunogenic peptide. MOG peptide (35-55) is specific to expanded CD4+ T cells, and induces experimental autoimmune encephalomyelitis (EAE) in animal model[1][2][3].

体外研究
(In Vitro)

The expanded CD4+ T cells are largely specific for the myelin oligodendrocyte glycoprotein (MOG) immunogenic peptide 35-55 (MOG35-55), while clonally expanded CD8+ T cells were non-responsive to myelin peptides or proteins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MOG peptide (35-55) 相关抗体:
体内研究
(In Vivo)

MOG peptide (35-55) (3 mg/mL for 0.1 mL; s.c.; single dose) results active induction of experimental autoimmune encephalomyelitis (EAE) in mice[2].
MOG peptide (35-55) (200 μg; s.c.; single dose) induces a increasing concentration of the eosinophil chemoattractant eotaxin-1 in the spinal cord in the course of EAE induced in C57BL/6 mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 129S1/SvImJ, C57BL/6 and C57BL/6 X SJL hybrid[2]
Dosage: 3 mg/mL, 0.1 mL per mice; accompanied with CFA and 4 mg/mL Mycobacterium tuberculosis
Administration: Subcutaneous injection; single dose
Result: Showed the expected signs of experimental autoimmune encephalomyelitis (EAE), which started with tail loss of tonus and continued in an ascending fashion in mice immunized with MOG35-55.
Animal Model: C57BL/6 mice (8-12 weeks)[3]
Dosage: 200 μg
Administration: Subcutaneous injection; single dose; analyzed at pre-onset (day 7 post immunization), onset (day 9-13 post immunization) and peak (day 17-19 post immunization)
Result: Increased eosinophil abundance in the spinal cord increases in the course of EAE.
分子量

2580.97

Formula

C118H178N36O28S
CAS 号
性状

固体

颜色

Off-white to light yellow

Sequence Shortening

MEVGWYRSPFSRVVHLYRNGK-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

H2O 中的溶解度 : ≥ 100 mg/mL (38.75 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.3875 mL 1.9373 mL 3.8745 mL
5 mM 0.0775 mL 0.3875 mL 0.7749 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 98.72%

COA (258 KB) LCMS (96 KB)

产品使用指南 (1538 KB)
参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.3875 mL 1.9373 mL 3.8745 mL 9.6863 mL
5 mM 0.0775 mL 0.3875 mL 0.7749 mL 1.9373 mL
10 mM 0.0387 mL 0.1937 mL 0.3875 mL 0.9686 mL
15 mM 0.0258 mL 0.1292 mL 0.2583 mL 0.6458 mL
20 mM 0.0194 mL 0.0969 mL 0.1937 mL 0.4843 mL
25 mM 0.0155 mL 0.0775 mL 0.1550 mL 0.3875 mL
30 mM 0.0129 mL 0.0646 mL 0.1292 mL 0.3229 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MOG peptide (35-55)2022956-48-3Othersexperimental autoimmune encephalomyelitisEAEexpanded CD4 T cellsInhibitorinhibitorinhibit

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