2. Anti-infection
  3. Antibiotic
  4. Mycalolide B

Mycalolide-B 是一种海绵肌动球蛋白 ATPase 特异性抑制剂。在 Ca2+ 存在时，Mycalolide-B 抑制 ATP 诱导的收缩和 Mg2+-ATPase 活性。

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Mycalolide B Chemical Structure

Mycalolide B Chemical Structure

CAS No. : 122752-21-0

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Mycalolide B 相关抗体

Top Publications Citing Use of Products

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mycalolide-B is a specific inhibitor of actomyosin ATPase isolated from marine sponge. Mycalolide-B inhibits ATP-induced contraction and Mg2+-ATPase activity in the absence of Ca2+[1].

IC50 & Target

actomyosin ATPase[1]
体外研究
(In Vitro)

Mycalolide-B belongs to macrolide antibiotics and consists of tris-oxazole with strong cytotoxic activity (IC50: 10-50 nM for growth of L1210 murine leukemia cells). Mycalolide-B, a toxin isolated from marine sponge, inhibits smooth muscle contractions without changing cytosolic Ca2+ levels. Mycalolide-B also inhibits Ca2+-induced contraction in permeabilized smooth muscles. Mycalolide-B inhibits superprecipitation and Mg2+-ATPase activity stimulated by Ca2+ without changing myosin light chain phosphorylation. Mycalolide-B inhibits ATP-induced contraction and Mg2+-ATPase activity in the absence of Ca2+[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mycalolide B 相关抗体:
分子量

1027.16

Formula

C52H74N4O17
CAS 号
结构分类
初始来源

marine sponge
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Mycalolide B 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mycalolide B122752-21-0Antibioticmacrolideantibioticstris-oxazolecytotoxicactivityL1210murineleukemiaInhibitorinhibitorinhibit

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目录号：
HY-N8493
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