2. Antibody-drug Conjugate/ADC Related Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. Drug-Linker Conjugates for ADC EGFR
  4. N3-PEG8-Phe-Lys-PABC-Gefitinib TFA

N3-PEG8-Phe-Lys-PABC-Gefitinib TFA 是由抗癌活性分子 Gefitinib (HY-50895) (口服活性的抑制剂) 和可降解 ADC linker N3-PEG8-Phe-Lys-PABC 组成的。N3-PEG8-Phe-Lys-PABC-Gefitinib TFA 是一种点击化学试剂。它含有 Azide 基团，可以和含有 Alkyne 基团的分子发生铜催化的叠氮-炔环加成反应（CuAAc)。它还可以和含有 DBCO 或 BCN 基团的分子发生环张力驱动的炔-叠氮环加成反应 (SPAAC)。

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N3-PEG8-Phe-Lys-PABC-Gefitinib TFA

N3-PEG8-Phe-Lys-PABC-Gefitinib TFA Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥4680
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Other Forms of N3-PEG8-Phe-Lys-PABC-Gefitinib TFA:

N3-PEG8-Phe-Lys-PABC-Gefitinib TFA 相关抗体

Top Publications Citing Use of Products

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Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

生物活性

N3-PEG8-Phe-Lys-PABC-Gefitinib TFA is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-tumor agent, Gefitinib (HY-50895) (orally active EGFR tyrosine kinase inhibitor), linked via the cleavable linker N3-PEG8-Phe-Lys-PABC. N3-PEG8-Phe-Lys-PABC-Gefitinib TFA is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

体外研究
(In Vitro)

ADC 由一个抗体和 ADC 细胞毒素通过 ADC 连接子连接而成。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

N3-PEG8-Phe-Lys-PABC-Gefitinib TFA 相关抗体:
分子量

1364.82

Formula

C62H82ClF4N11O17
性状

固体

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料

N3-PEG8-Phe-Lys-PABC-Gefitinib TFA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N3-PEG8-Phe-Lys-PABC-GefitinibDrug-Linker Conjugates for ADCEGFREpidermal growth factor receptorErbB-1HER1agent-linker conjugate for ADCGefitinibInhibitorinhibitorinhibit

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