1. Anti-infection
  2. Bacterial
  3. Nebacumab

Nebacumab  (Synonyms: HA-1A; Septomonab)

目录号: HY-P99751

Nebacumab (HA-1A) 是一种单克隆抗体,可与内毒素的脂质 A 部分结合。Nebacumab 可用于败血症的研究。

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Nebacumab Chemical Structure

Nebacumab Chemical Structure

CAS No. : 138661-01-5

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nebacumab (HA-1A) is a monoclonal antibody that binds to lipid A portion of endotoxin. Nebacumab can be used of research of sepsis[1][2].

体外研究
(In Vitro)

Nebacumab (24 μg/mL,24 小时) 在全身炎症反应综合征 (SIRS) 患者的全血中诱导产生 IL-6[2]
Nebacumab (0-100 μg/mL) 抑制外周血单核细胞产生 TNF-α、IL-1β 和 IL-6[3]
Nebacumab (1 和 100 μg/mL,14 天) 抑制内毒素对大鼠中耳上皮细胞的增殖和形态学影响[4]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Nebacumab (3 mg/kg,静脉注射) 降低感染了 E.coli 的小鼠的内毒素循环水平[5]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice infected with E.coli[5]
Dosage: 3 mg/kg
Administration: i.v.
Result: Reduced the levels of circulating endotoxin.
Reduced mesenteric lymph nodes.
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Nebacumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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HY-P99751
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