1. Metabolic Enzyme/Protease
  2. Dipeptidyl Peptidase
  3. NVP-DPP728 dihydrochloride

NVP-DPP728 dihydrochloride 是一种高效、选择性的二肽基肽酶 IV (DPP-IV) 抑制剂,其 Ki 为 11 nM。NVP-DPP728 dihydrochloride 可用于糖尿病的研究。

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NVP-DPP728 dihydrochloride Chemical Structure

NVP-DPP728 dihydrochloride Chemical Structure

CAS No. : 207556-62-5

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NVP-DPP728 dihydrochloride is a potent, selective and orally active dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 11 nM. NVP-DPP728 dihydrochloride can be used for the research of diabetes mellitus[1][2].

IC50 & Target

Ki: 11 nM (DPP-IV) [1]

体外研究
(In Vitro)

NVPDPP728 inhibits human and rat plasma DPP-IV (IC50s: 5-10 nM) with >15 000-fold selectivity relative to DPP-II and a range of proline-cleaving proteases[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

NVP-DPP728 (3.72 mg/kg; p.o.) inhibits DPP-IV and improves insulin secretion and glucose tolerance, probably through augmentation of the effects of endogenous GLP-1[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Obese (fa/fa) and lean (FA/?) Zucker rats[2]
Dosage: 3.72 mg/kg
Administration: Oral administration
Result: Led to inhibition of plasma DPP-IV activity.
分子量

371.26

Formula

C15H20Cl2N6O

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

NVP-DPP728 dihydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
NVP-DPP728 dihydrochloride
目录号:
HY-14293
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