2. Metabolic Enzyme/Protease
  3. LDLR
  4. Orticumab

Orticumab  (Synonyms: MLDL1278A)

目录号: HY-P99793 纯度: ≥99.0%
COA

摩尔计算器

Orticumab (MLDL1278A) 是一种靶向氧化或丙二醛修饰的脂蛋白 (LDL) 的抗体。Orticumab 特异性抑制氧化低密度脂蛋白 (oxLDL)。Orticumab 参与调节针对 oxLDL 的自身免疫反应，可改善动物模型的动脉粥样硬化。Orticumab 也可用于改善银屑病的研究。

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Orticumab Chemical Structure

Orticumab Chemical Structure

CAS No. : 1314241-10-5

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规格 价格 是否有货 数量
1 mg ￥3200
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Orticumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Orticumab (MLDL1278A) is an antibody targeting to oxidized or malondialdehyde-modified lipoprotein (LDL). Orticumab specifically inhibits oxidized low-density lipoproteins (oxLDL). Orticumab involves in modulation of autoimmune responses against oxLDL, improves atherosclerosis in animal model. Orticumab also can be used for research of psoriasis improvement[1][2].

体外研究
(In Vitro)

Orticumab (10 μg/mL；24 小时) 增加 oxLDL 刺激后体外培养的 PBMC 中的 CD14+ ICOS-L+ 群体[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Orticumab 相关抗体:
体内研究
(In Vivo)

Orticumab (10 毫克/小鼠；腹腔注射；每周一次，持续 3 周) 减少主动脉弓中的动脉粥样硬化，减少 CD68 巨噬细胞瓣膜下斑块染色[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B6.lpr.ApoE-/- mice (18-week-old) fed with high-fat diet (HFD)[1]
Dosage: 10 mg/mouse
Administration: Intraperitoneal injection; once weekly for 3 weeks
Result: Reduced atherosclerosis in the aortic arch by 42.8%, decreased the CD68-macrophage subvalvular plaque staining by 30.5%.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: ≥99.0%

COA (172 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Orticumab 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Orticumab1314241-10-5MLDL1278ALDLRLow-density lipoprotein receptorInhibitorinhibitorinhibit

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