2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. PD-1/PD-L1-IN-24

PD-1/PD-L1-IN-24 是一种高效的 PD-1/PD-L1 抑制剂，IC50 为 1.57 nM。PD-1/PD-L1-IN-24 通过提高 IFN-γ 来在细胞水平上恢复 T 细胞功能。PD-1/PD-L1-IN-24 对 PBMCs 具有较低的细胞毒性。

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PD-1/PD-L1-IN-24 Chemical Structure

PD-1/PD-L1-IN-24 Chemical Structure

CAS No. : 2667680-33-1

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PD-1/PD-L1-IN-24 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PD-1/PD-L1-IN-24 is a highly potent PD-1/PD-L1 inhibitor with IC50 value of 1.57 nM. PD-1/PD-L1-IN-24 can restore T-cell function at the cellular level by significantly elevating the IFN-γ level. PD-1/PD-L1-IN-24 has low toxicity on the PBMCs[1].

IC50 & Target

IC50: 1.57 nM (PD-1/PD-L1)[1]
体外研究
(In Vitro)

PD-1/PD-L1-IN-24 (compound 39) (0-10 μM; 6 hours) significantly releases PD-L1-mediated inhibition of PD-1-expressing Jurkat T cells at the concentration of 10 μM[1].
PD-1/PD-L1-IN-24 (0.003-20 μM; 72 hours) exhibits no significant toxicity at concentrations ranging from 0.003 to 2.22 μM, and the IC50 is 12.42 μM[1].
PD-1/PD-L1-IN-24 (0.082, 0.247, 0.741 and 2.222 μM; 72 hours) significantly elevates the secretion of IFN-γ with a dose-dependent manner in T cell-tumor co-culture cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PD-1/PD-L1-IN-24 相关抗体:

Cell Cytotoxicity Assay

Cell Line: PBMC[1]
Concentration: 0.003, 0.0091, 0.027, 0.082, 0.247, 0.741, 2.222, 6.67 and 20 μM
Incubation Time: 72 hours
Result: No significant toxicity was observed at concentrations ranging from 0.003 to 2.22 μM, and the IC50 was 12.42 μM.
分子量

640.08

Formula

C34H30ClN5O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PD-1/PD-L1-IN-24 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD-1/PD-L1-IN-242667680-33-1PD-1/PD-L1PD-1/Programmed death-ligand 1Quinazoline derivativesPD-1/PD-L1 interactionT cellTumorCell toxicityIFN-γPBMCsInhibitorinhibitorinhibit

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