1. GPCR/G Protein Neuronal Signaling
  2. Dopamine Receptor
  3. PD 119819

PD 119819 是一种高选择性 benzopyran-4-one brain dopamine autoreceptor 激动剂。PD 119819 是一种杂环哌嗪,可抑制自发运动活动和脑 dopamine 合成。

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PD 119819 Chemical Structure

PD 119819 Chemical Structure

CAS No. : 105277-43-8

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PD 119819 is a highly selective benzopyran-4-one brain dopamine autoreceptor agonist. PD 119819, a heterocyclic piperazine, inhibits spontaneous locomotor activity and brain dopamine synthesis[1][2].

IC50 & Target[1]

Dopamine Receptor

 

体内研究
(In Vivo)

PD 119819 (5~80 mg/kg; nasogastric intubation) makes monkeys show marked increases in alanine aminotransferase levels and a moderate increase in ornithine carbamyltransferase levels at the initial sampling interval after doses of 5 mg/kg with peak levels occurring after doses of 20 or 60 mg/kg, while lower values is evident after doses of 80 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkey[1]
Dosage: 5~80 mg/kg
Administration: Nasogastric intubation
Result: Made monkeys show marked increases in alanine aminotransferase levels and a moderate increase in ornithine carbamyltransferase levels at the initial sampling interval after doses of 5 mg/kg with peak levels occurring after doses of 20 or 60 mg/kg, while lower values were evident after doses of 80 mg/kg.
分子量

438.35

Formula

C21H25Cl2N3O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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产品名称:
PD 119819
目录号:
HY-118402
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