1. Immunology/Inflammation
  2. Salt-inducible Kinase (SIK)
  3. Phanginin A

Phanginin A 是一种有效的具有口服活性的 SIK1 激活剂。Phanginin A 抑制糖异生。Phanginin A 增加 p-SIK1 的表达并降低 p-CREB 的表达。Phanginin A 可降低血糖水平并改善葡萄糖耐量和血脂异常。Phanginin A 具有用于 2 型糖尿病研究的潜力。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Phanginin A Chemical Structure

Phanginin A Chemical Structure

CAS No. : 1011528-58-7

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Phanginin A is a potent and orally active SIK1 (salt-induced kinase 1) activator. Phanginin A inhibited gluconeogenesis. Phanginin A increases the expression of p-SIK1 and decreases the expression of p-CREB. Phanginin A reduces blood glucose levels and improves glucose tolerance and dyslipidemia. Phanginin A has the potential for the research of type 2 diabetes[1].

IC50 & Target[1]

SIK1

 

体外研究
(In Vitro)

Phanginin A (2.5, 5, 10 µM) 以剂量依赖性方式抑制原代小鼠肝细胞中的糖异生[1]
Phanginin A (5, 10 µM) 降低 G6P 和 PEPCK 的 mRNA 表达,并减少细胞内 cAMP 的积累[1]
Phanginin A (5, 10 µM; 0-120 min) 以时间和剂量依赖的方式抑制原代小鼠肝细胞中 CREB 磷酸化的表达[1]
Phanginin A (2.5, 5, 10 µM; 0-120 min) 以时间和剂量依赖的方式增加原代小鼠肝细胞中 p-SIK1 的表达[1]
Phanginin A (5, 10 µM) 增加 PDE4 活性[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: Primary mouse hepatocytes
Concentration: 5, 10 µM
Incubation Time:
Result: Significantly decreased PEPCK mRNA expression by 25% and 43% under basal conditions and 45% and 67% under forskolin-stimulated conditions, The G6P mRNA expression was also significantly reduced, with 5 and 10 μM of phanginin A resulting in a decrease of 30% and 46% under basal conditions and 38% and 57% under forskolin-stimulated conditions, respectively.

Western Blot Analysis[1]

Cell Line: Primary mouse hepatocytes
Concentration: 0-120 min
Incubation Time:
Result: Inhibited CREB phosphorylation in a time and dose-dependent manner.
体内研究
(In Vivo)

Phanginin A (100 mg/kg; p.o.; once) 在 2 型糖尿病 ob/ob 小鼠中表现出抗糖异生活性[1]
Phanginin A (100 mg/kg; p.o.; once daily for 26 days) 改善 ob/ob 小鼠的代谢紊乱[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Type 2 diabetic ob/ob mice[1]
Dosage: 100 mg/kg
Administration: P.o.; once
Result: Significantly reduced the blood glucose, increased the phosphorylation of SIK1 in the liver by 119%, PDE4 activity in the liver was elevated by 74%, decreased in the cAMP concentration along with a 46% decrease in the CREB phosphorylation level in the liver, decreased the mRNA levels of PEPCK and G6P.
Animal Model: Male ob/ob mice[1]
Dosage: 100 mg/kg
Administration: P.o.; once daily for 26 days
Result: Showed an average reduction rate of 29% and 32% in random and fast blood glucose, exhibited a marked improvement in glucose tolerance, significantly reduced by 20% in HbA1c level, showed no effect on food intake and body weight.
分子量

360.44

Formula

C21H28O5

CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
Phanginin A
目录号:
HY-N9539
需求量: