2. Protein Tyrosine Kinase/RTK Metabolic Enzyme/Protease
  3. SHP2 Phosphatase
  4. PHPS1

PHPS1 是一种有效的选择性 Shp2 抑制剂，对 Shp2，Shp2-R362K，Shp1，PTP1B 和 PTP1B-Q 的 Ki 值分别为 0.73，5.8，10.7，5.8 和 0.47 μM。

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PHPS1 Chemical Structure

PHPS1 Chemical Structure

CAS No. : 314291-83-3

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规格 价格 是否有货 数量
1 mg ￥460
In-stock
5 mg ￥1100
In-stock
10 mg ￥1700
In-stock
25 mg ￥3300
In-stock
50 mg ￥4650
In-stock
100 mg ￥6500
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of PHPS1:

PHPS1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PHPS1 is a potent and selective Shp2 inhibitor with Kis of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively[1].

IC50 & Target

Ki: 0.73 μM (Shp2), 5.8 μM (Shp2-R362K), 10.7 μM (Shp1), 5.8 μM (PTP1B), 0.47 μM (PTP1B-Q)[1]
体外研究
(In Vitro)

PHPS1 (30 μM；6 天) 抑制人类肿瘤细胞的增殖[1]。
PHPS1 (5 -20 μM；5-360 分钟) 剂量依赖性抑制 Erk1/2 但不抑制 Akt 和 Stat3 磷酸化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PHPS1 相关抗体:

Cell Viability Assay[1]

Cell Line: Human cancer cell lines MDA-MB-435, HCT-116 (colon carcinoma), HCT-15 (colon carcinoma), PC-3 (prostate carcinoma) HT-29 (colon carcinoma), NCI-H661 (lung carcinoma), and Caki-1 (kidney carcinoma)
Concentration: 30 μM
Incubation Time: 6 days
Result: Resulted in a reduction in cell number of between 0% (Caki-1) to 74% (HT-29).

Western Blot Analysis[1]

Cell Line: Madin-Darby canine kidney (MDCK) cells
Concentration: 5, 10, 20 μM
Incubation Time: 5, 15, 60, 120, 360 minutes
Result: Inhibited HGF/SF (1 unit/mL)-induced phosphorylation and thus activation of Erk1/2 over a time period of 15 min to 6 h. In contrast, transient phosphorylation of Erk1/2 after 5 min was not affected.
Exhibited no effect on HGF/SF-induced activation of PI3K/Akt or Stat3.
体内研究
(In Vivo)

PHPS1 (3 mg/kg；腹腔注射；高脂肪饮食的最后一周的每一天) 使 Ldlr-/- 小鼠不易发生动脉粥样硬化[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ldlr-/- (005061) mice[2]
Dosage: 3 mg/kg
Administration: Intraperitoneal (i.p.) injection; every day during the last week on the high-fat diet.
Result: Revealed a significant decrease in atherosclerotic plaque size in the aorta compared with the other two groups.
分子量

465.44

Formula

C21H15N5O6S
CAS 号
性状

固体

颜色

Red to reddish brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 25 mg/mL (53.71 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1485 mL 10.7425 mL 21.4850 mL
5 mM 0.4297 mL 2.1485 mL 4.2970 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

PHPS1 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1485 mL 10.7425 mL 21.4850 mL 53.7126 mL
5 mM 0.4297 mL 2.1485 mL 4.2970 mL 10.7425 mL
10 mM 0.2149 mL 1.0743 mL 2.1485 mL 5.3713 mL
15 mM 0.1432 mL 0.7162 mL 1.4323 mL 3.5808 mL
20 mM 0.1074 mL 0.5371 mL 1.0743 mL 2.6856 mL
25 mM 0.0859 mL 0.4297 mL 0.8594 mL 2.1485 mL
30 mM 0.0716 mL 0.3581 mL 0.7162 mL 1.7904 mL
40 mM 0.0537 mL 0.2686 mL 0.5371 mL 1.3428 mL
50 mM 0.0430 mL 0.2149 mL 0.4297 mL 1.0743 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PHPS1314291-83-3PHPS 1PHPS-1SHP2PhosphataseSrc homology phosphatase 2PTPN11Shp2Shp1PTP1BErk1/2atherosclerosiscancercoloncarcinomaprostatelungkidneyInhibitorinhibitorinhibit

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产品名称：
PHPS1
目录号：
HY-112368
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