2. Apoptosis Protein Tyrosine Kinase/RTK
  3. Apoptosis FGFR
  4. Picrasidine Q

Picrasidine Q 是从当归植物中提取的生物碱成分，具有抗细胞转化和抗癌作用。Picrasidine Q 诱导人食管癌细胞凋亡和G1 期阻滞，并直接抑制 FGFR2 激酶活性。

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Picrasidine Q Chemical Structure

Picrasidine Q Chemical Structure

CAS No. : 101219-61-8

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Picrasidine Q 相关抗体

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查看 FGFR 亚型特异性产品:

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FGFR FGFR1 FGFR2 FGFR3 FGFR4 FGF21

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Picrasidine Q, an alkaloid component extracted from Angelica keiskei species, has the capacity of anti-cell transformation and anti-cancer. Picrasidine Q induces cell apoptosis and G1 phase arrest in human esophageal cancer cell lines, and directly inhibits FGFR2 kinase activity[1].

IC50 & Target[1]

FGFR2

 

体外研究
(In Vitro)

Picrasidine Q (0~60 μM; 3 hours; ESCC cells) suppresses downstream signaling of FGFR2 in ESCC cells[1].
Picrasidine Q (0~60 μM; 48 and 72 hours; ESCC cells) induces cell cycle arrest and apoptosis[1].
Picrasidine Q (0~60 μM; 24~72 hours; ESCC cells) suppresses the growth of ESCC cells[1].
Picrasidine Q (0~60 μM; 30 minutes; JB6Cl41 cells) inhibits proliferation by inhibition of G1/S cell cycle transition[1].
Picrasidine Q (12.5, 25 or 50 μM) can inhibit the FGFR2 kinase activity in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Picrasidine Q 相关抗体:

Western Blot Analysis[1]

Cell Line: ESCC cells
Concentration: 0~60 μM
Incubation Time: 3 hours
Result: Suppressed downstream signaling of FGFR2 in ESCC cells.

Apoptosis Analysis[1]

Cell Line: ESCC cells
Concentration: 0~60 μM
Incubation Time: 48 and 72 hours
Result: Induced cell cycle arrest and apoptosis.

Cell Cytotoxicity Assay[1]

Cell Line: ESCC cells
Concentration: 0~60 μM
Incubation Time: 24~72 hours
Result: Suppressed the growth of ESCC cells.

Cell Cycle Analysis[1]

Cell Line: JB6Cl41 cells
Concentration: 0~60 μM
Incubation Time: 30 minutes
Result: Inhibited proliferation by inhibition of G1/S cell cycle transition.
分子量

266.25

Formula

C15H10N2O3
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Picrasidine Q 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Picrasidine Q101219-61-8ApoptosisFGFRFibroblast growth factor receptoralkaloidcomponentAngelicakeiskeitransformationanticancerInhibitorinhibitorinhibit

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