1. Antibody-drug Conjugate/ADC Related
  2. Antibody-Drug Conjugates (ADCs)
  3. Pivekimab sunirine

Pivekimab sunirine  (Synonyms: IMGN 632; PVEK)

目录号: HY-P99774

Pivekimab sunirine (IMGN 632) 是一种靶向 CD123抗体-药物偶联物 (ADC)。Pivekimab sunirine 包含高亲和力的 CD123 抗体、可裂解连接子和 indolinobenzodiazepine pseudodimer (IGN)。Pivekimab sunirine 可用于血液恶性肿瘤的研究。

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Pivekimab sunirine Chemical Structure

Pivekimab sunirine Chemical Structure

CAS No. : 2417174-95-7

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Pivekimab sunirine (IMGN 632) is an antibody-drug conjugate (ADC) targeting CD123. Pivekimab sunirine comprises a high-affinity CD123 antibody, cleavable linker, and an indolinobenzodiazepine pseudodimer (IGN) payload. Pivekimab sunirine can be used for research of hematological malignancies[1][2].

(In Vitro)

Pivekimab sunirine (4-6 天) 在 AML 细胞系中表现出细胞毒性,IC50 为 0.6 pM-40 pM[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: EOL-1, HNT-34, KASUMI-3, KG-1, KO52, MOLM-13, MV4-11, SHI-1, SKM-1, UCSD-AML1 cells
Concentration: 0-1 nM approximately
Incubation Time: 4-6 days
Result: Showed cytotoxicity with IC50s of 0.6 pM-40 pM.
(In Vivo)

Pivekimab sunirine (40-240 μg/kg, i.p.) 在人 AML 小鼠异种移植模型中导致肿瘤消退[2]
Pivekimab sunirine (8 和 80 μg/kg,i.p.) 可延长播散性 Molm-13 异种移植模型小鼠的寿命[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human AML xenograft model[2]
Dosage: 40, 80, 240 μg/kg
Administration: I.p.
Result: Induced complete and durable tumor regression at 240 μg/kg.

Please store the product under the recommended conditions in the Certificate of Analysis.

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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