1. 重组蛋白
  2. Viral Proteins
  3. Hepatitis C Virus Proteins

Hepatitis C Virus Proteins  (丙型肝炎病毒蛋白)

Hepatitis C virus (HCV) is a positive-strand RNA virus grouped in the genus Hepacivirus within the family Flaviviridae. HCV is classified into at least 6 genotypes (gt), and its error-prone polymerase leads to more than 50 subtypes. The long open reading frame, which encodes the HCV polyprotein, is processed by host and viral proteases and gives rise to three structural proteins (the capsid protein core and envelope glycoproteins E1 and E2) and seven nonstructural (NS) proteins (p7, NS2, NS3, NS4A, NS4B, NS5A, and NS5B). NS2 and p7 are essential for virus assembly but not RNA replication, whereas NS3 to NS5B are involved in a membrane-associated RNA replicase complex (RC). The NS3 protein is composed of a serine protease and an RNA helicase/nucleoside triphosphatase (NTPase), NS4A serves as a cofactor for NS3 serine protease, NS5B is the RNA-dependent RNA polymerase, and NS5A is considered to play key roles in multiple steps of the HCV life cycle.NS5A inhibitors exhibit a rapid inhibition of virus infectivity shortly after administration to HCV-infected cells. The HCV protein NS5A prevents the apoptosis-enabling loss of intracellular potassium by inhibiting Kv2.1 function and thus blocking hepatocyte cell death. The HCV RNA-dependent RNA polymerase (RdRp) has long been a prime target for antiviral development because of its critical role in viral replication and the absence of a mammalian homologous enzyme. The combination of lucidone and alpha interferon, the protease inhibitor Telaprevir, the NS5A inhibitor BMS-790052, or the NS5B polymerase inhibitor PSI-7977, synergistically suppresses HCV RNA replication.

目录号 产品名 / 同用名 种属 表达系统
  • HY-P74183
    E2/Envelope Protein, Hepatitis C virus (HEK293, His)

    HCV-1a E2 Protein; Hepatitis C virus (serotype 1b, isolate HC-J4) Envelope/E2 Protein

    Virus HEK293
  • HY-P74184
    E2/Envelope Protein, Hepatitis C virus (aa384-661, HEK293, His)

    Hepatitis C virus (HCV) (serotype 1c,isolate HC-G9) E2 Protein (His Tag); HCV-1a E2 Protein

    Virus HEK293
  • HY-P74185
    E2/Envelope Protein, Hepatitis C virus (278a.a, HEK293, His)

    Hepatitis C virus (HCV) (serotype 1c,isolate HC-G9) E2 Protein (His Tag); HCV-1a E2 Protein

    Virus HEK293
  • HY-P74899
    Envelope Glycoprotein E1 Protein, HCV (HEK293, His)

    HCV-E1 Protein; Hepatitis C virus Envelope Glycoprotein E1 / HCV-E1 (subtype 1b, strain HC-J4) Protein

    Virus HEK293
    Envelope Glycoprotein E1 蛋白是丙型肝炎病毒中发现的包膜糖蛋白的两个亚基之一,是一种 1 型跨膜蛋白。它与包膜糖蛋白 E2 作为非共价异二聚体结合,介导病毒附着于宿主细胞、通过网格蛋白依赖性内吞作用介导病毒粒子内化以及与宿主膜的融合。E1/E2 异二聚体结合宿主载脂蛋白。它也可以与 CD81 结合可激活上皮生长因子受体 (EGFR) 信号通路。Envelope Glycoprotein E1 Protein, HCV (HEK293, His) 是重组的 包膜糖蛋白 E1 蛋白,由 HEK293 表达,带有 N-His 标签。Envelope Glycoprotein E1 Protein, HCV (HEK293, His) 全长 149 个氨基酸,分子量约为 ~18.7 kDa。
目录号 产品名 作用方式 纯度