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Dexfadrostat  (Synonyms: (R)-Fadrozole; (R)-CGS 16949A free base; FAD286)

目录号: HY-113986
产品使用指南

Dexfadrostat ((R)-Fadrozole) 是有效的非甾体类抑制剂。Dexfadrostat 还抑制人胎盘芳香化酶 (pIC50 = 6.17) 和醛固酮生物合成。Dexfadrostat 能逆转自发性高血压心力衰竭大鼠的心脏纤维化。

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Dexfadrostat Chemical Structure

Dexfadrostat Chemical Structure

CAS No. : 102676-87-9

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dexfadrostat ((R)-Fadrozole) is a potent nonsteroidal inhibitor[1]. Dexfadrostat also inhibits human placental aromatase (pIC50 = 6.17) and aldosterone biosynthesis. Dexfadrostat reverses cardiac fibrosis in spontaneously hypertensive heart failure rats.[1][2].

IC50 & Target

pIC50: 6.17 (human placental aromatase)

体外研究
(In Vitro)

The (-)-enantiomer with the S-absolute configuration was responsible for the high aromatase inhibitory activity of Dexfadrostat[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Dexfadrostat ((R)-fadrozole; 0.24 and 1.2 mg/kg; daily; oral) and (S)-fadrozole similarly decreases plasma aldosterone levels, whereas urinary aldosterone excretion rate was reduced only by S-fadrozole[2].
Dexfadrostat (0.24 and 1.2 mg/kg; daily; oral) effectively reverses preexistent left ventricular interstitial fibrosis by 50% (vs. 42% for canrenoate), S-fadrozole was devoid of an antifibrotic effect[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SHHF rats[2]
Dosage: 0.24 and 1.2 mg/kg
Administration: Daily; oral
Result: Decreased plasma aldosterone levels and reversed preexistent left ventricular interstitial fibrosis.
分子量

223.27

Formula

C14H13N3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Dexfadrostat 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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