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ABCD1 蛋白, Human (His)

目录号: HY-P72012
产品使用指南

ABCD1, Human (His) 是亚家族 D 中四种 ATP 结合盒 (ABC) 蛋白之一。ABCD1 的功能障碍会导致神经退行性疾病。

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描述

ABCD1, Human (His) is one of the four ATP-binding cassette (ABC) proteins in subfamily D. Dysfunction of ABCD1 causes neurodegenerative disorder X-linked adrenoleukodystrophy (X-ALD).

研究背景

ALDP contains six putative transmembrane domains (TMDs) and a nucleotide-binding domain (NBD). ALDP is synthesized on free polysomes, post-translationally transported to peroxisomes, and inserted into the membranes. During this process, ALDP interacts with Pex19p, a chaperone-like protein for intracellular trafficking of PMP, the complex is targeted to Pex3p on the peroxisomal membranes and then ALDP is inserted into the membranes. After integration into the membranes, ALDP is thought to form mainly a homodimer and in part a heterodimer with other peroxisomal ABC proteins such as 70-kDa peroxisomal membrane protein (PMP70/ABCD3) and adrenoleukodystrophy-related protein (ALDRP/ABCD2). Dysfunction of ABCD1 causes neurodegenerative disorder X-linked adrenoleukodystrophy (X-ALD), which is characterized by the abnormal accumulation of VLCFA due to impaired peroxisomal β-oxidation[1][2].

生物活性

Measured by its binding ability in a functional ELISA. Immobilized ABCD1 at 5 μg/mL can bind human PEX19, the EC50 of human PEX19 protein is 22.96-33.00 μg/mL.

种属

Human

表达系统

E. coli

标签

C-10*His

蛋白编号

P33897 (M1-T745)

基因 ID

215  [NCBI]

同用名
ABC42; Abcd1; ABCD1_HUMAN; Adrenoleukodystrophy protein; ALD; Aldgh; ALDP; AMN; ATP binding cassette; sub family D ALD; member 1; ATP-binding cassette sub-family D member 1; OTTHUMP00000025960; OTTMUSP00000019283; RGD1562128; RP23 373N8.2; X linked adrenoleukodystrophy ALD; gene homolog
氨基酸序列

MPVLSRPRPWRGNTLKRTAVLLALAAYGAHKVYPLVRQCLAPARGLQAPAGEPTQEASGVAAAKAGMNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLARCIVRKDPRAFGWQLLQWLLIALPATFVNSAIRYLEGQLALSFRSRLVAHAYRLYFSQQTYYRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTAWPSAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVELALLQRSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGYSESDAEAVKKAALEKKEEELVSERTEAFTIARNLLTAAADAIERIMSSYKEVTELAGYTARVHEMFQVFEDVQRCHFKRPRELEDAQAGSGTIGRSGVRVEGPLKIRGQVVDVEQGIICENIPIVTPSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGGVLYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQREGGWEAMCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLSITHRPSLWKYHTHLLQFDGEGGWKFEKLDSAARLSLTEEKQRLEQQLAGIPKMQRRLQELCQILGEAVAPAHVPAPSPQGPGGLQGAST

分子量

Approximately 84.9 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

性状

Lyophilized powder.

组分

Lyophilized from a 0.2 μm sterile filtered Tris-based buffer, 50% Glycerol.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in sterile distilled water.

保存条件 & 期限

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US;may vary elsewhere.

文件资料
参考文献

ABCD1 Protein, Human (His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific active calculator equation

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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