1. 重组蛋白
  2. Immune Checkpoint Proteins Biotinylated Proteins
  3. Inhibitory Checkpoint Molecules
  4. B7-H4
  5. B7-H4 蛋白, Human (HEK293, His-Avi)

B7-H4 蛋白, Human (HEK293, His-Avi)

目录号: HY-P78390
产品使用指南

B7-H4 蛋白充当负调节因子,抑制 T 细胞介导的免疫反应,包括激活、增殖、细胞因子产生和细胞毒性。当在肿瘤巨噬细胞上表达时,它与调节性 T 细胞合作抑制肿瘤相关抗原特异性 T 细胞免疫。B7-H4 的参与延伸到促进上皮细胞转化,展示了其在调节免疫反应和与肿瘤发展相关的过程中的多方面作用。B7-H4 蛋白, Human (HEK293, His-Avi) 是重组的 B7-H4 蛋白,由 HEK293 表达,带有 C-His, C-Avi 标签。B7-H4 蛋白, Human (HEK293, His-Avi) 全长 230 个氨基酸,分子量为 52-68 kDa。

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描述

B7-H4 protein acts as a negative regulator, inhibiting T-cell-mediated immune responses, including activation, proliferation, cytokine production, and cytotoxicity. When expressed on tumor macrophages, it collaborates with regulatory T-cells to suppress tumor-associated antigen-specific T-cell immunity. B7-H4's involvement extends to promoting epithelial cell transformation, showcasing its multifaceted role in modulating immune responses and processes linked to tumor development. B7-H4 Protein, Human (HEK293, His-Avi) is the recombinant human-derived B7-H4 protein, expressed by HEK293, with C-His, C-Avi labeled tag. The total length of B7-H4 Protein, Human (HEK293, His-Avi) is 230 a.a., with molecular weight of 52-68 kDa.

研究背景

B7-H4 蛋白作为 T 细胞介导的免疫反应的负调节因子,对 T 细胞活化、增殖、细胞因子产生和细胞毒性的发展发挥抑制作用。当在肿瘤巨噬细胞的细胞表面表达时,B7-H4 与调节性 T 细胞 (Treg) 合作,在抑制肿瘤相关抗原特异性 T 细胞免疫方面发挥着至关重要的作用。此外,B7-H4 还参与促进上皮细胞转化,表明其多方面参与调节免疫反应和与肿瘤发展相关的细胞过程。

种属

Human

表达系统

HEK293

标签

C-His;C-Avi

蛋白编号

Q7Z7D3 (F29-A258)

基因 ID
蛋白结构
N-term
B7-H4 (F29-A258)
Accession # Q7Z7D3
His-Avi
C-term
同用名
B7H4; B7-H4; B7S1; B7h.5; B7x; FLJ22418; VTCN1; PRO1291
分子量

52-68 kDa

纯度

Greater than 95% as determined by Tris-Bis PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

B7-H4 Protein, Human (HEK293, His-Avi) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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B7-H4 Protein, Human (HEK293, His-Avi)
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HY-P78390
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