1. 重组蛋白
  2. Immune Checkpoint Proteins CD Antigens
  3. Inhibitory Checkpoint Molecules Macrophage CD Proteins
  4. BTLA BTLA/CD272
  5. BTLA/CD272 蛋白, Human (104a.a, HEK293, Fc)

BTLA/CD272 蛋白, Human (104a.a, HEK293, Fc)

目录号: HY-P72858
产品使用指南

BTLA/CD272 蛋白在淋巴细胞上表达,是抗原受体信号传导的负调节因子。它与酪氨酸磷酸酶 PTPN6/SHP-1 和 PTPN11/SHP-2 相互作用,调节免疫反应并维持淋巴细胞稳态。 BTLA 与 TNFRSF14 发生顺式和反式相互作用;顺式相互作用调节幼稚 T 细胞,抑制反式相互作用以维持静息状态。在适应性免疫反应期间,主要的反式相互作用向效应 T 细胞提供生存信号。这种复杂的相互作用凸显了 BTLA 在免疫调节中的多方面作用。BTLA/CD272 蛋白, Human (104a.a, HEK293, Fc) 是重组的 BTLA/CD272 蛋白,由 HEK293 表达,带有 C-hFc 标签。BTLA/CD272 蛋白, Human (104a.a, HEK293, Fc) 全长 104 个氨基酸,分子量约为 ~42.2 kDa。

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描述

BTLA/CD272 Protein, expressed on lymphocytes, is a negative regulator of antigen receptor signaling. Interacting with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2, it modulates immune responses and maintains lymphocyte homeostasis. BTLA engages in cis and trans interactions with TNFRSF14; cis interactions regulate naive T cells, inhibiting trans interactions to maintain a resting state. During adaptive immune responses, predominant trans interactions provide survival signals to effector T cells. The intricate interplay highlights BTLA's multifaceted role in immune regulation. BTLA/CD272 Protein, Human (104a.a, HEK293, Fc) is the recombinant human-derived BTLA/CD272 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of BTLA/CD272 Protein, Human (104a.a, HEK293, Fc) is 104 a.a., with molecular weight of ~42.2 kDa.

研究背景

BTLA/CD272 是淋巴细胞上表达的抑制性受体,通过与酪氨酸磷酸酶 PTPN6/SHP-1 和 PTPN11/SHP-2 相互作用,充当抗原受体信号传导的负调节因子。这些相互作用有助于调节免疫反应和维持淋巴细胞稳态。 BTLA 可能与 TNFRSF14 发生顺式和反式相互作用,顺式相互作用在幼稚 T 细胞中发挥调节作用,抑制反式相互作用以维持静息状态。相比之下,在适应性免疫反应期间占主导地位的反式相互作用为效应 T 细胞提供生存信号。 BTLA 与其结合伙伴之间错综复杂的相互作用强调了其在免疫调节中的多方面作用。

种属

Human

表达系统

HEK293

标签

C-hFc

蛋白编号

Q7Z6A9-2 (K31-T134)

基因 ID
蛋白结构
N-term
BTLA (K31-T134)
Accession # Q7Z6A9-2
hFc
C-term
同用名
B-and T-lymphocyte attenuator; CD272; BTLA
氨基酸序列

MKTLPAMLGTGKLFWVFFLIPYLDIWNIHGKESCDVQLYIKRQSEHSILAGDPFELECPVKYCANRPHVTWCKLNGTTCVKLEDRQTSWKEEKNISFFILHFEPVLPNDNGSYRCSANFQSNLIESHSTTLYVT

分子量

Approximately 42.2 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
BTLA/CD272 Protein, Human (104a.a, HEK293, Fc)
目录号:
HY-P72858
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